Development of a new therapeutic approach against chemo-resistance of leukemic stem cells by bone marrow microenvironment
Project/Area Number |
22790907
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Hematology
|
Research Institution | National Hospital Organization Nagoya Medical Center |
Principal Investigator |
MIYATA Yasuhiko 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), 血液内科, 医長 (40467303)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 血液腫瘍学 / 薬剤耐性 |
Research Abstract |
Direct contact with bone marrow stromal cells provides CML-derived cell lines with dormancy similar to stem cells and induced-drug resistance. In these cells, up-regulation of anti-apoptotic protein BCL-2 and p53 was observed and was thought to lead to this resistance, suggesting that the molecular targeted therapy toward these proteins could be reasonable. Moreover, up-regulation of BCR-ABL protein and elongation of BCR-ABL mRNA were observed by contact with stromal cells. This indicates that cell-to-cell contact may be involved in post-transcriptional regulation of mRNA.
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Report
(4 results)
Research Products
(30 results)