| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Direct contact with bone marrow stromal cells provides CML-derived cell lines with dormancy similar to stem cells and induced-drug resistance. In these cells, up-regulation of anti-apoptotic protein BCL-2 and p53 was observed and was thought to lead to this resistance, suggesting that the molecular targeted therapy toward these proteins could be reasonable. Moreover, up-regulation of BCR-ABL protein and elongation of BCR-ABL mRNA were observed by contact with stromal cells. This indicates that cell-to-cell contact may be involved in post-transcriptional regulation of mRNA.
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