Control of leukemic stem cells by the bone marrow microenvironments
| Project/Area Number |
22790910
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 血液腫瘍学 / 白血病幹細胞ニッチ / 白血病 / ケモカイン / CXCR4 |
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| Research Abstract |
In the bone marrow, leukemic stem cells(LSCs), the most important target for leukemic therapy, are maintained by special microenvironments, termed niches. The nature and function of these niches, however, remains unclear. Here we showed that using mouse chronic myeloid leukemia model,(1) the microenvironments in bone marrow were altered with progression of leukemia,(2) LSCs grew up in altered microenvironments,(3) B lymphopoiesis in the bone marrow was impaired along with elevated inflammatory cytokines(e. g. IL6), and(4) identified candidates of cell components of LSC niches. These studies offer innovative strategies for leukemia therapy targeting the LSCs niches.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] CXCL12-CXCR4 chemokine signaling is essential for NK cell development in adult mice.2010
Author(s)
Noda, M., Omatsu, Y., Sugiyama, T., Oishi, S., Fujii, N., and *Nagasawa, T.
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Journal Title
Blood
Volume: 117
Issue: 2
Pages: 451-458
DOI
Related Report
Peer Reviewed
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