| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
In the bone marrow, leukemic stem cells(LSCs), the most important target for leukemic therapy, are maintained by special microenvironments, termed niches. The nature and function of these niches, however, remains unclear. Here we showed that using mouse chronic myeloid leukemia model,(1) the microenvironments in bone marrow were altered with progression of leukemia,(2) LSCs grew up in altered microenvironments,(3) B lymphopoiesis in the bone marrow was impaired along with elevated inflammatory cytokines(e. g. IL6), and(4) identified candidates of cell components of LSC niches. These studies offer innovative strategies for leukemia therapy targeting the LSCs niches.
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