Analysis of epigenetic aberration in plasma cell dyscrasia
| Project/Area Number |
22790917
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
YASUI Hiroshi 札幌医科大学, 道民医療推進学講座, 助教 (40448593)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 血液内科学 / 難治性形質細胞疾患 / 多発性骨髄腫 / DNAメチル化 / 脱メチル化剤 / 抗癌剤感受性 / ゲノムワイド / 染色体異常 / 次世代シーケンサー / デキサメサゾン感受性 |
|---|
| Research Abstract |
We analyzed gene expression profile in MM cells treated with or without demethylating agent to screen for the tumor related genes silenced by DNA methylation. We next examined the effect of DNA hypomethylation in retrotransposon for chromosomal aberration. Patients in MM with chromosomal deletion showed significant lower LINE-1 methylation levels than patients without deletion suggesting that LINE-1 hypomethylation are associated with chromosomal instability. Our ongoing study is to decipher the methylome in MM cells using high-throughput next-generation sequencer ; and assess the association between the methylome status and the genome status.
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Report
(3 results)
Research Products
(25 results)
