Development of antigen specific therapy for rheumatoid arthritis

• Project/Area Number: 22790926
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: The University of Tokyo
• Principal Investigator: SHODA Hirofumi 東京大学, 医学部附属病院, 助教 (20529036)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 関節リウマチ / 新規治療法 / T細胞 / HLA-DRB1多型 / BiP / HLA-DRB1 / Interleukin

Research Abstract

We identified autoantigen BiP-derived HLA-DR4 epitopes in rheumatoid arthritis(RA) patients. BiP-specific CD4+T cells increased both in peripheral blood and synovial tissues of RA. This subset produced pro-inflammatory cytokine, interleukin(IL)-17, and could have a close association with RA pathogenesis. Moreover, oral administration of this BiP epitope ameliorated mouse models of RA significantly. These observations support the possibility of the development of antigen-specific therapy for RA.

Research Products

• [Journal Article] Autoantigen BiP and autoimmune diseases (2012)
  • Author(s): Shoda H, et al
  • Journal Title: 日本臨床免疫学会誌 Volume: 35(1) Pages: 46-50
  • NAID: 10030465607
• [Journal Article] Detection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and pro-inflammatory role of citrullinated BiP in collagen-induced arthritis (2011)
  • Author(s): Shoda H, Fujio K, Shibuya M, Okamura T, Sumitomo S, Okamoto A, Sawada T, et al.
  • Journal Title: Arthritis Res Ther Volume: 13 Issue: 6 Pages: 1-12
  • DOI: 10.1186/ar3520
  • Peer Reviewed
• [Presentation] Autoantigen BiP-specific CD4+T cells in rheumatoid arthritis and systemic lupus erythematosus patients (2011)
  • Author(s): 庄田宏文他
  • Organizer: 第40回日本免疫学会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-28
• [Presentation] Autoantigen BiP-specific CD4+ T cells in rheumatoid arthritis and systemic lupus erythematosus patients (2011)
  • Author(s): 庄田宏文, ほか
  • Organizer: 日本免疫学会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-28
• [Presentation] 自己BiP由来epitopeを認識するCD4陽性T細胞の健常人・関節リウマチ患者における表現型 (2011)
  • Author(s): 庄田宏文他
  • Organizer: 第55回日本リウマチ学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2011-07-19
• [Presentation] Identification of autoantigen BiP-derived HLA-DR4 epitope and its pathological roles in rheumatoid arthritis (2010)
  • Author(s): 庄田宏文他
  • Organizer: 第14回国際免疫学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-08-24
• [Presentation] Identification of autoantigen BiP-derived HLA-DR4 epitope and its pathological roles in rheumatoid arthritis (2010)
  • Author(s): 庄田宏文
  • Organizer: 第14回国際免疫学会
  • Place of Presentation: 神戸 国際展示場
  • Year and Date: 2010-08-24