Development of antigen specific therapy for rheumatoid arthritis
Project/Area Number |
22790926
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
膠原病・アレルギー・感染症内科学
|
Research Institution | The University of Tokyo |
Principal Investigator |
SHODA Hirofumi 東京大学, 医学部附属病院, 助教 (20529036)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 関節リウマチ / 新規治療法 / T細胞 / HLA-DRB1多型 / BiP / HLA-DRB1 / Interleukin |
Research Abstract |
We identified autoantigen BiP-derived HLA-DR4 epitopes in rheumatoid arthritis(RA) patients. BiP-specific CD4+T cells increased both in peripheral blood and synovial tissues of RA. This subset produced pro-inflammatory cytokine, interleukin(IL)-17, and could have a close association with RA pathogenesis. Moreover, oral administration of this BiP epitope ameliorated mouse models of RA significantly. These observations support the possibility of the development of antigen-specific therapy for RA.
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Report
(3 results)
Research Products
(7 results)