| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
Aire is a gene responsible for the hereditary type of human autoimmune disease. Elucidation of the mechanisms underlying the Aire-deficient autoimmune pathogenesis would contribute to unveiling the pathogenesis of autoimmune disease. In order to know how the Aire establishes the immune tolerance, we constructed the experimental system where we get the information on the cellular dynamics of Aire-expressing cells. Unexpectedly, we found that Aire is expressed by early embryos prior to the thymic organogenesis. Furthermore, we demonstrated that half-life of Aire-expressing cells is about 1 week, which turned out to be much longer than previously thought.
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