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Functional analysis of the gene responsible for the hereditary type of human autoimmune disease

Research Project

Project/Area Number 22790931
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionThe University of Tokushima

Principal Investigator

NISHIKAWA Yumiko  徳島大学, 疾患酵素学研究センター, 学術研究員 (60448214)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords胸腺 / 自己免疫疾患 / AIRE / 細胞分化 / 遺伝子改変マウス / 自己寛容
Research Abstract

Aire is a gene responsible for the hereditary type of human autoimmune disease. Elucidation of the mechanisms underlying the Aire-deficient autoimmune pathogenesis would contribute to unveiling the pathogenesis of autoimmune disease. In order to know how the Aire establishes the immune tolerance, we constructed the experimental system where we get the information on the cellular dynamics of Aire-expressing cells. Unexpectedly, we found that Aire is expressed by early embryos prior to the thymic organogenesis. Furthermore, we demonstrated that half-life of Aire-expressing cells is about 1 week, which turned out to be much longer than previously thought.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (28 results)

All 2012 2011 2010 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (22 results) Remarks (1 results)

  • [Journal Article] Rab13 small G protein and Junctional Rab13-binding protein (JRAB) orchestrate actin cytoskeletal organization during epithelial Junctional development2012

    • Author(s)
      Sakane, A., Abdallah, A.A.M., Nakano, K., Honda, K., Ikeda, W., Nishikawa, Y., Matsumoto, M., Matsushita, N., Kitamura. T., and Sasaki, T
    • Journal Title

      J. Biol. Chem

      Volume: 287(51) Issue: 51 Pages: 42455-424680

    • DOI

      10.1074/jbc.m112.383653

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma2011

    • Author(s)
      Mouri Y
    • Journal Title

      Journal of Immunology

      Volume: 186 Issue: 9 Pages: 5047-5057

    • DOI

      10.4049/jimmunol.1003533

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-21-dependent B cell death driven by prostaglandin E2, a product secre ted from follicular dendritic cells2011

    • Author(s)
      Magari, M.Ohmori, H., et al
    • Journal Title

      Journal of Immunology

      Volume: 187 Issue: 8 Pages: 4210-4218

    • DOI

      10.4049/jimmunol.1100934

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biphasic Aire expression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation.2010

    • Author(s)
      Nishikawa Y, Hirota F, Yano M, Kitajima H, Miyazaki J, Kawamoto H, Mouri Y, Matsumoto M
    • Journal Title

      J Exp Med.

      Volume: 207 Issue: 5 Pages: 963-971

    • DOI

      10.1084/jem.20092144

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biphasic Aire expression in early embryos and in medullary thymic epithelial cells priorto end-stage terminal differentiation2010

    • Author(s)
      Nishikawa, Y., et al.
    • Journal Title

      J.Exp.Med.

      Volume: Vol.207 Pages: 963-971

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Timing-controlled fate-mapping study reveals essential roles of Aire in the maturation program of Aire-expressing cell lineage2012

    • Author(s)
      Nishikawa, Y., Mouri, Y., Nishijima, H, and Matsumoto, M
    • Organizer
      第41回日本免疫学会総会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2012-12-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Cell-cycle dependent phosphorylation of AIRE protein exogenously expressed in HeLa cells2012

    • Author(s)
      Nishijima, H., et al
    • Organizer
      4th International Conference on Drug Discovery & Therapy
    • Place of Presentation
      Dubai, United Arab Emirates
    • Year and Date
      2012-02-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Temporal fate-mapping approach reveals a requirement of Aire for the full maturation program of thymic epithelial cells in the medulla2012

    • Author(s)
      Nishikawa, Y., and Matsumoto, M
    • Organizer
      International Symposium on Genetic and Epigenetic Control of Cell Fate
    • Place of Presentation
      Kyoto Grand Prince Hotel(京都市)
    • Related Report
      2012 Final Research Report
  • [Presentation] Temporal fate-mapping approach reveals a requirement of Aire for the full maturation program of thymic epithelial cells in the medulla2012

    • Author(s)
      Nishikawa Y.
    • Organizer
      International Symposium on Genetic and Epigenetic Control of Cell Fate
    • Place of Presentation
      グランドプリンスホテル京都(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Timing-controlled fate-mapping study reveals essential roles of Aire in the maturation program of Aire-expressing cell lineage2012

    • Author(s)
      Nishikawa Y.
    • Organizer
      第41回日本免疫学会総会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] AIRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化2011

    • Author(s)
      西嶋 仁、毛利安宏、西川裕美子、松本 満
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2011-11-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Negative selectionにおけるAire発現細胞由来自己抗原の役割2011

    • Author(s)
      毛利安宏、西川裕美子、西嶋 仁、松本 満
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2011-11-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of self-antigen expressed by Aire-expressing cells in the negative selection process2011

    • Author(s)
      Matsumoto, M., et al
    • Organizer
      5th International Conference on Autoimmunity : Mechanisms and Novel Treatments
    • Place of Presentation
      Crete, Greece
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] セミ・ノッタインマウスを用いた時期特異的Aire発現細胞のfate mapping解析2011

    • Author(s)
      西川裕美子, 他
    • Organizer
      第21回Kyoto T Cell Conference
    • Place of Presentation
      京都平安ホテル(京都府)
    • Year and Date
      2011-06-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma2011

    • Author(s)
      Mouri, Y., et al
    • Organizer
      13^<th> International TNF Conference, TNF 2011
    • Place of Presentation
      Awaji, Hyogo, Japan
    • Year and Date
      2011-05-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of Aire in the organization of thymic microenvironment2011

    • Author(s)
      Matsumoto, M., et al.
    • Organizer
      Controversies in Rheumatology and Autoimmunity (CORA 2011)
    • Place of Presentation
      Firenze Fiera, Florence, Italy
    • Year and Date
      2011-03-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of self-antigen expressed by Aire-expressing cells in the negative selection process2011

    • Author(s)
      Matsumoto, M., Mouri, Y., Nishikawa, Y., and Nishijima, H
    • Organizer
      5th International Conference on Autoimmunity: Mechanisms and Novel Treatments
    • Place of Presentation
      Knossos Royal Village Conference Center, Hersonissos, Crete, Greece
    • Related Report
      2012 Final Research Report
  • [Presentation] Aire-dependent organization of thymic microenvironment for the establishment of self tolerance2011

    • Author(s)
      Matsumoto, M., Nishikawa, Y., Mouri, Y., and Nishijima, H
    • Organizer
      EUThyme-Rolduc Meeting
    • Place of Presentation
      NH Conference Center, Leeuwenhorst, The Netherlands
    • Related Report
      2012 Final Research Report
  • [Presentation] Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma2011

    • Author(s)
      Mouri, Y., Yano, M.,Shinzawa, M., Shimo, Y., Nishikawa, Y., Tamada, K., Chen, L., Penninger, J.M., Inoue, J., Akiyama, T., and Matsumoto, M
    • Organizer
      13thInternational TNF Conference, TNF 2011
    • Place of Presentation
      Awaji Yumebutai International Conference Center(淡路市)
    • Related Report
      2012 Final Research Report
  • [Presentation] Aire-dependent organization of thymic microenvironment for the establishment of self-tolerance2011

    • Author(s)
      Nishikawa, Y., Mouri, Y., Nishijima, H., and Matsumoto, M
    • Organizer
      ESF-JSPS Frontier Science Conference Series for Young Researchers 「Cutting Edge Immunology and its Clinical Application」
    • Place of Presentation
      Apollo Hotel de Beyaerd, Hulshort, The Netherlands
    • Related Report
      2012 Final Research Report
  • [Presentation] Roles of thymic epithelial cells for the establishment of self-tolerance2010

    • Author(s)
      Matsumoto, M., et al.
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe Portopia Hotel, Kobe, Japan
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Aire in thymic epithelial cells in the medulla controls developmental process of thymocytes2010

    • Author(s)
      Mouri, Y., Nishikawa, Y., and Matsumoto, M
    • Organizer
      14thInternational Congress of Immunology
    • Place of Presentation
      Kobe Portopia Hotel(神戸市)
    • Year and Date
      2010-08-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Aire in thymic epithelial cells in the medulla controls developmental process of thymocytes2010

    • Author(s)
      Mouri, Y., et al.
    • Organizer
      14^<th> international Congress of Immunology
    • Place of Presentation
      Kobe Portopia Hotel, Kobe, Japan
    • Year and Date
      2010-08-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Biphasic Aire expression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation2010

    • Author(s)
      Nishikawa, Y., Mouri, Y., and Matsumoto, M
    • Organizer
      14thInternational Congress of Immunology
    • Place of Presentation
      Kobe Portopia Hotel(神戸市)
    • Year and Date
      2010-08-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Biphasic Aire expression in early embryos and in medullary thymic epithelial cells priorto end-stage terminal differentiation2010

    • Author(s)
      Nishikawa, Y., et al.
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe Portopia Hotel, Kobe, Japan
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] AIRE and autoimmune disease2010

    • Author(s)
      Matsumoto, M., Nishikawa, Y., Hirota, F. and Mouri, Y
    • Organizer
      The 19th International Rheumatology Symposium
    • Place of Presentation
      Kobe Portopia Hotel(神戸市)
    • Year and Date
      2010-04-23
    • Related Report
      2012 Final Research Report
  • [Presentation] AIRE and autoimmune disease2010

    • Author(s)
      Matsumoto, M., et al.
    • Organizer
      The 19^<th> International Rheumatology Symposium
    • Place of Presentation
      Kobe Portopia Hotel, Kobe, Japan
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://mms1.ier.tokushima-u.ac.jp/article/0017775.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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