Analysis of vicious circle in atopic dermatitis
| Project/Area Number |
22790934
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アレルギー / アトピー性皮膚炎 / periostin / Th2 / 細胞外マトリックス / Periostin |
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| Research Abstract |
Atopic dermatitis(AD) is a chronic inflammatory skin disease characterized by skin barrier impairment and immunologic abnormalities, in which Th2 type responses dominate. In this study, we identified that a vicious circle constituted with IL-4/ IL-13, periostin, and TSLP, is involved in the pathogenesis of AD and that the inhibition of this circle prevents the pathogenesis of AD.
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Report
(3 results)
Research Products
(54 results)
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[Journal Article] Periostin, a matricellular protein, accelerates cutaneous wound repair by activating dermal fibroblasts2012
Author(s)
Ontsuka K, Kotobuki Y, Shiraishi H, Serada S, Ohta S, Tanemura A, Yang L, Fujimoto M, Arima K, Suzuki S, Murota H, Toda S, Kudo A, Conway SJ, Narisawa Y, Katayama I, Izuhara K, Naka T.
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Journal Title
Exp Dermatol
Volume: 21
Pages: 331-336
Related Report
Peer Reviewed
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[Journal Article] Periostin, a matricellular protein, plays a role in the induction of chemokines in pulmonary fibrosis2012
Author(s)
Uchida M, Shiraishi H, Ohta S, Arima K, Taniguchi K, Suzuki S, Okamoto M, Ahlfeld SK, Ohshima K, Kato S, Toda S, Sagara H, Aizawa H, Hoshino T, Conway SJ, Hayashi S, Izuhara K.
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Journal Title
Am J Respir Cell Mol Biol
Volume: 46
Pages: 677-686
Related Report
Peer Reviewed
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[Journal Article] Periostin, a matric protein, is a novel biomarker for idiopathic interstitial pneumonias2011
Author(s)
Okamoto M, Hoshino T, Kitasato Y, Sakazaki Y, Kawayama T, Fujimoto K, Ohshima K, Shiraishi H, Uchida M, Ono J, Ohta S, Kato S, Izuhara K, Aizawa H.
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Journal Title
Eur Respir J
Volume: 37
Pages: 1119-1127
Related Report
Peer Reviewed
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[Journal Article] Endotoxin tolerance attenuates airway allergic inflammation in model mice by suppression of the T-cell stimulatory effect of dendritic cells2010
Author(s)
Matsushita H, Ohta S, Shiraishi H, Suzuki S, Arima K, Toda S, Tanaka H, Nagai H, Kimoto M, Inokuchi A, Izuhara K.
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Journal Title
Int Immunol
Volume: 22
Pages: 739-747
NAID
Related Report
Peer Reviewed
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[Journal Article] Periostin promotes chronic allergic inflammation in response to Th2 cytokines
Author(s)
Masuoka M, Shiraishi H, Ohta S, Suzuki S, Arima K, Aoki S, Toda S, Inagaki N, Kurihara Y, Hayashida S, Takeuchi S, Koike K, Ono J, Noshiro H, Furue M, Conway SJ, Narisawa Y, Izuhara K.
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Journal Title
J Clin Invest
Volume: in press
Related Report
Peer Reviewed
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[Presentation] Periostin, a matrix protein, is a novel serodiagnostic marker for cholangiocarcinoma2010
Author(s)
Kawaguchi T, Fujimoto K, Nakashima O, Suzuki S, Shiraishi H, Ohta S, Kawaguchi A, Tonan T, Oshima K, Yano H, Hayabuchi N, Izuhara K, sata M.
Organizer
The 61^<th> annual meeting of the American association for the study of Liver diseases. The Liver Meeting
Place of Presentation
Boston
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