| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Atopic dermatitis(AD) is a chronic inflammatory skin disease characterized by skin barrier impairment and immunologic abnormalities, in which Th2 type responses dominate. In this study, we identified that a vicious circle constituted with IL-4/ IL-13, periostin, and TSLP, is involved in the pathogenesis of AD and that the inhibition of this circle prevents the pathogenesis of AD.
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