Research Project
Grant-in-Aid for Young Scientists (B)
Thymic stromal lymphopoietin(TSLP) is a cytokine that plays an important role in the development of allergic inflammation. It was shown to activate human dendritic cells to promote Th2-type immune response. We examined the detailed signal transduction mechanism of TSLP. The multiple signal pathways activated by TSLP were selectively down-regulated by the Th1-inducing agents such as TLR ligands. Furthermore, we successfully established a cell line that demonstrates activation of the similar signal pathways by TSLP to those in dendritic cells. This cell line will be of great help in analyzing biochemical properties of the TSLP signal transduction
All 2012 2011 2010 Other
All Journal Article (19 results) (of which Peer Reviewed: 6 results) Presentation (10 results) Book (6 results) Remarks (3 results) Patent(Industrial Property Rights) (9 results) (of which Overseas: 1 results)
Allergol Int
Volume: 61 Pages: 35-43
130004873041
Inflamm Regen
Volume: 32 Pages: 23-31
130004482289
Am J Respir Cell Mol Biol
Volume: (Epub ahead of print)
Exp Dermatol
Volume: 21 Pages: 331-336
臨床免疫・アレルギー科
Volume: 57 Pages: 227-233
Volume: 57 Pages: 104-110
呼吸と循環
Volume: 60 Pages: 179-187
40019187927
検査と技術
Volume: 40 Pages: 157-160
Allergology International
Volume: 61 Issue: 1 Pages: 35-43
10.2332/allergolint.11-RAI-0376
Inflammation and Regeneration
Volume: (In press) Issue: 5 Pages: 677-686
10.1165/rcmb.2011-0115oc
Experimental Dermatology
Volume: 21(5) Issue: 5 Pages: 331-336
10.1111/j.1600-0625.2012.01454.x
40019192543
生化学
Volume: 83 Pages: 1109-1113
10030345925
J Immunol
Volume: 184 Pages: 2999-3007
Int Immunol
Volume: 22 Pages: 739-747
10030913704
International Immunology
http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php