| Project/Area Number |
22790937
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Nagasaki University |
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Principal Investigator |
TAMAI Mami 長崎大学, 保健・医療推進センター, 助教 (60380862)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAKAMI Atsushi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (90325639)
UETANI Masataka 長崎大学, 大学院・医歯薬学総合研究科, 教授 (40176582)
AOYAGI Kiyoshi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (80295071)
ARIMA Kazuhiko 長崎大学, 大学院・医歯薬学総合研究科, 助教 (30423635)
YAMASAKI Satoshi 広島大学, 病院・リウマチ・膠原病科, 助教 (30367388)
KAWASHIRI Shin-ya 長崎大学, 医歯薬学総合研究科, 助教 (20457576)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | リウマチ学 / 関節リウマチ / 真の寛解 / 疾患活動性 / 関節MRI骨髄浮腫 |
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| Research Abstract |
To investigate the true remission in rheumatoid arthritis(RA), we studied very early RA with poor prognosis factors. Treatment with synthetic disease-modifying anti-rheumatic drugs reduced RA progression from undifferentiated arthritis. Significant improvement in MRI-proven bone edema may be associated with protection against structural damage(rs=0. 65, p<0. 05) and persistent remission during 12 months in very early RA patients managed using the tight control approach. The frequency of peripheral blood regulatory T cells in patients with RA negatively correlated with disease activity score, CRP and ESR. The regulatory T cell frequency of patients with RA in remission was similar to that of healthy controls.
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