Role of Chitin in Allergic Responses

• Project/Area Number: 22790941
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Kyorin University
• Principal Investigator: ARAE Ken 杏林大学, 保健学部, 助教 (50306669)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: アレルギー学 / アレルギー / Th2 / キチン / IL-33

Research Abstract

We investigated the role of chitin(a polymer of N-acetyl D-glucosamine) in the pathogenesis of allergic asthma in mice. The development of airway inflammation after intranasal sensitization with OVA/chitin and following intranasal challenge with OVA was significantly suppressed in IL-33-deficient mice. It is suggesting that chitin acts as a novel adjuvant in the induction of allergic responses involved in the onset of various allergic disorders via the IL-33/ST2 pathway.

Research Products

• [Journal Article] ST2 Requires Th2-, but Not Th17-, Type Airway Inflammation in Epicutaneously Antigen-Sensitized Mice (2012)
  • Author(s): Morita H, Arae K, Ohno T, Kajiwara N, Oboki K, Matsuda A, Suto H, Okumura K, Sudo K, Takahashi T, Matsumoto K, Nakae S
  • Journal Title: Allergol Int Volume: (In press)
  • NAID: 130004477129
  • Peer Reviewed
• [Journal Article] Mycoplasma pneumoniae induces interleukin-8 production via the epidermal growth factor receptor pathway (2011)
  • Author(s): Arae K, Hirata M, Kurata S, Kamiya S, Taguchi H
  • Journal Title: Microbiol Immunol Volume: 55(10) Pages: 748-750
  • NAID: 10031121528
  • Peer Reviewed
• [Journal Article] Cimetidine enhances antigen-specific IgE and Th2 cytokine production (2011)
  • Author(s): Arae K, Oboki K, Ohno T, Hirata M, Nakae S, Taguchi H, Saito H, Nakajima T
  • Journal Title: Allergol Int Volume: 60(3) Pages: 339-344
  • NAID: 130004723046
  • Peer Reviewed
• [Journal Article] Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation (2011)
  • Author(s): Ohno T, Oboki K, Morita H, Kajiwara N, Arae K, Tanaka S, Ikeda M, Iikura M, Akiyama T, Inoue J, Matsumoto K, Sudo K, Azuma M, Okumura K, Kamradt T, Saito H, Nakae S
  • Journal Title: PLoS One Volume: 6(4)
• [Journal Article] Cimetidine Enhances Antigen-Specific IgE and Th2 Cytokine Production. (2011)
  • Author(s): Arae K, Oboki K, Ohno T, Hirata M, Nakae S, Taguchi H, Saito H, Nakajima T.
  • Journal Title: Allergol Int. Volume: (ePub ahead of print)
  • NAID: 130004723046
  • Peer Reviewed
• [Journal Article] IL-33 is a crucial amplifier of innate rather than acquired immunity (2010)
  • Author(s): Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, Kiyonari H, Matsumoto K, Sudo K, Okumura K, Saito H, Nakae S
  • Journal Title: Proc Natl Acad Sci U S A Volume: 107(43) Pages: 18581-18586
• [Journal Article] Development of IL-17-mediated delayed-type hypersensitivity is not affected by down-regulation of IL-25 expression (2010)
  • Author(s): Ishii A, Oboki K, Nambu A, Morita H, Ohno T, Kajiwara N, Arae K, Sudo H, Okumura K, Saito H, Nakae S
  • Journal Title: Allergol Int Volume: 59(4) Pages: 399-408
  • NAID: 10029671236
  • Peer Reviewed
• [Journal Article] Paracrine IL-33 Stimulation Enhances Lipopolysaccharide-Mediated Macrophage Activation. (2010)
  • Author(s): Ohno T, Oboki K, Morita H, Kajiwara N, Arae K, Tanaka S, Ikeda M, Iikura M, Akiyama T, Inoue J, Matsumoto K, Sudo K, Azuma M, Okumura K, Kamradt T, Saito H, Nakae S.
  • Journal Title: PLoS One. Volume: VOL.6
  • Peer Reviewed
• [Journal Article] IL-33 is a crucial amplifier of innate rather than acquired immunity. (2010)
  • Author(s): Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, Kiyonari H, Matsumoto K, Sudo K, Okumura K, Saito H, Nakae S.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: VOL.107 Pages: 18581-6
  • Peer Reviewed
• [Journal Article] Development of IL-17-mediated delayed-type hypersensitivity is not affected by down-regulation of IL-25 expression. (2010)
  • Author(s): Ishii A, Oboki K, Nambu A, Morita H, Ohno T, Kajiwara N, Arae K, Sudo H, Okumura K, Saito H, Nakae S.
  • Journal Title: Allergol Int. Volume: VOL.59 Pages: 399-408
  • NAID: 10029671236
  • Peer Reviewed