Role of basophils in allergic inflammation induced by mite-or pollen-derived proteases
| Project/Area Number |
22790943
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Juntendo University |
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Principal Investigator |
KAMIJOU Seiji 順天堂大学, 医学研究科, 助教 (00445470)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | アレルゲン / プロテアーゼ / 好塩基球 / Th2アジュバント |
|---|
| Research Abstract |
Present study showed that house dust mite allergens as well as pollen-derived substances such as proteases, eicosanoid-like lipids and NADPH oxidase modulate the maturation and/or cytokine production of dendritic cells and basophils in favor of Th2 differentiation, and that substances derived from allergenic organisms function as Th2 adjuvant in the murine allergic airway inflammation model.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Extracellular double-stranded RNA induces TSLP via an endosomal acidification-and NF-κB-dependent pathway in human keratinocytes2011
Author(s)
Vu AT, Chen X, Xie Y, Kamijo S, Ushio H, Kawasaki J, Hara M, Ikeda S, Okumura K, Ogawa H, Takai T
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Journal Title
J Invest Dermatol
Volume: 131(11)
Pages: 2205-12
Related Report
Peer Reviewed
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[Journal Article] Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes through the Toll-like receptor 2-Toll-like receptor 6 pathway2010
Author(s)
Vu AT, Baba T, Chen X, Le TA, Kinoshita H, Xie Y, Kamijo S, Hiramatsu K, Ikeda S, Ogawa H, Okumura K, Takai T
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Journal Title
J Allergy Clin Immunol
Volume: 126(5)
Pages: 985-993
Related Report
Peer Reviewed
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