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Roles of IL-17 family cytokines in airway hyper responses

Research Project

Project/Area Number 22790944
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionThe University of Tokyo

Principal Investigator

NAMBU Aya  東京大学, 医科学研究所, 特任研究員 (10456197)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords免疫 / サイトカイン / 免疫学 / アレルギー / 遺伝子 / 動物
Research Abstract

In this study I had tried to understand the roles of IL-25 and IL17B in a airway hyper responses (AHR). In a mouse model of allergic AHR, IL-17E derived from epithelial cells has a critical role by recruiting eosinophils to local inflammation sites.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (11 results)

All 2012 2011 2010

All Journal Article (9 results) (of which Peer Reviewed: 7 results) Presentation (2 results)

  • [Journal Article] Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma.2012

    • Author(s)
      Suzukawa M, Morita H, Nambu A, Arae K,Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Korner H, Cua DJ, Suto H,Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide DH,Matsumoto K, Nakae S.
    • Journal Title

      J immunol.

      Volume: 189(7) Issue: 7 Pages: 3641-52

    • DOI

      10.4049/jimmunol.1200461

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Th17 cel1-derived IL-17 is dispensable for B cell antibody production.2012

    • Author(s)
      Akiko Shibui
    • Journal Title

      Cytokine

      Volume: 1 Issue: 1 Pages: 108-114

    • DOI

      10.1016/j.cyto.2012.03.018

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma.2012

    • Author(s)
      Suzukawa M
    • Journal Title

      J Immunol.

      Volume: 189(7) Pages: 3641-52

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Th17 cell-derived IL-17 is dispensable for B cell antibody production2012

    • Author(s)
      Shibui A, Shimura E, Nambu A, Yamaguchi S, Leonard WJ, Okumura K, Sugano S, Sudo K, Nakae S
    • Journal Title

      Cytokine

      Volume: (Epub ahead of print)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of Immune Responses by N-acetylglucosaminyltransferase V during Allergic Airway Inflammation2011

    • Author(s)
      Akiko Shibui
    • Journal Title

      Allergology International

      Volume: 60 Issue: 3 Pages: 345-354

    • DOI

      10.2332/allergolint.10-OA-0283

    • NAID

      130004723047

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion2011

    • Author(s)
      S.Itoh
    • Journal Title

      Circulation

      Volume: 124 Issue: 11_suppl_1

    • DOI

      10.1161/circulationaha.110.014852

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-33 is a crucial amplifier of innate rather than acquired immunity.2010

    • Author(s)
      Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, KiyonariH, Matsumoto K, Sudo K, Okumura K, SaitoH, Nakae S.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 107(43) Issue: 43 Pages: 18581-6

    • DOI

      10.1073/pnas.1003059107

    • Related Report
      2012 Final Research Report
  • [Journal Article] Development of IL-17-mediated Delayed-Type Hypersensitivity Is Not Affected by Down-Regulation of IL-25 Expression2010

    • Author(s)
      Ishii A, Oboki K, Nambu A, Morita H, OhnoT, Kajiwara N, Arae K, Sudo H, Okumura K, Saito H, Nakae S.
    • Journal Title

      Allergology International

      Volume: 59 Issue: 4 Pages: 399-408

    • DOI

      10.2332/allergolint.10-OA-0218

    • NAID

      10029671236

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Journal Article] IL-33 is a crucial amplifier of innate rather than acquired immunity.2010

    • Author(s)
      Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, Kiyonari H, Matsumoto K, Sudo K, Okumura K, Saito H, Nakae S.
    • Journal Title

      Proc Natl Acad Sci U.S.A.

      Volume: 107(43) Pages: 18581-6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Regulation and function of IL-162010

    • Author(s)
      南部あや、角木基彦、中江進
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] Regulation and function of IL-162010

    • Author(s)
      南部あや、角木基彦、中江進
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸 ポートピアホテル
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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