Roles of IL-17 family cytokines in airway hyper responses
Project/Area Number |
22790944
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
膠原病・アレルギー・感染症内科学
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Research Institution | The University of Tokyo |
Principal Investigator |
NAMBU Aya 東京大学, 医科学研究所, 特任研究員 (10456197)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 免疫 / サイトカイン / 免疫学 / アレルギー / 遺伝子 / 動物 |
Research Abstract |
In this study I had tried to understand the roles of IL-25 and IL17B in a airway hyper responses (AHR). In a mouse model of allergic AHR, IL-17E derived from epithelial cells has a critical role by recruiting eosinophils to local inflammation sites.
|
Report
(4 results)
Research Products
(11 results)
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[Journal Article] Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma.2012
Author(s)
Suzukawa M, Morita H, Nambu A, Arae K,Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Korner H, Cua DJ, Suto H,Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide DH,Matsumoto K, Nakae S.
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Journal Title
J immunol.
Volume: 189(7)
Issue: 7
Pages: 3641-52
DOI
Related Report
Peer Reviewed
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[Journal Article] IL-33 is a crucial amplifier of innate rather than acquired immunity.2010
Author(s)
Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, KiyonariH, Matsumoto K, Sudo K, Okumura K, SaitoH, Nakae S.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 107(43)
Issue: 43
Pages: 18581-6
DOI
Related Report
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[Journal Article] Development of IL-17-mediated Delayed-Type Hypersensitivity Is Not Affected by Down-Regulation of IL-25 Expression2010
Author(s)
Ishii A, Oboki K, Nambu A, Morita H, OhnoT, Kajiwara N, Arae K, Sudo H, Okumura K, Saito H, Nakae S.
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Journal Title
Allergology International
Volume: 59
Issue: 4
Pages: 399-408
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
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[Journal Article] IL-33 is a crucial amplifier of innate rather than acquired immunity.2010
Author(s)
Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, Kiyonari H, Matsumoto K, Sudo K, Okumura K, Saito H, Nakae S.
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Journal Title
Proc Natl Acad Sci U.S.A.
Volume: 107(43)
Pages: 18581-6
Related Report
Peer Reviewed
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