Mechanisms for allergen-induced airway inflammation regulated by non-adoptive immune system.

• Project/Area Number: 22790951
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: National Research Institute for Child Health and Development
• Principal Investigator: OBOKI Keisuke 独立行政法人国立成育医療研究センター, 免疫アレルギー研究部, 上級研究員 (80415108)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: サイトカイン / 喘息 / IL-33 / アレルギー

Research Abstract

Our results suggest that allergen Der f 1 or papain induce airway inflammation solely by its protease activity in the rapid time course.

Research Products

• [Journal Article] ST2 Requires Th2-, but Not Th17-, Type Airway Inflammation in Epicutaneously Antigen-Sensitized Mice (2012)
  • Author(s): Morita H, Arae K, Ohno T, Kajiwara N, Oboki, K, Matsuda A, Suto H, Okumura K, Sudo K, Takahashi T, Matsumoto K, Nakae, S
  • Journal Title: Allergology International Volume: 61 Issue: 2 Pages: 265-273
  • DOI: 10.2332/allergolint.11-OA-0379
  • NAID: 130004477129
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness (2012)
  • Author(s): Sawaguchi, M.
  • Journal Title: J.Immunol. Volume: 188 Issue: 4 Pages: 1809-1818
  • DOI: 10.4049/jimmunol.1101746
  • Peer Reviewed
• [Journal Article] Cimetidine Enhances Antigen-Specific IgE and Th2 Cytokine Production (2011)
  • Author(s): Arae K, Oboki, K, Ohno T, Hirata M, Nakae, S, Taguchi H, Saito, H, Nakajima T
  • Journal Title: Allergology International Volume: 60 Issue: 3 Pages: 339-344
  • DOI: 10.2332/allergolint.10-OA-0255
  • NAID: 130004723046
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Okumura K., Kamradt T., Saito H., Nakae S. Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage (2011)
  • Author(s): Ohno T., Oboki K., Kajiwara N., Tanaka S., Ikeda M., Iikura M., Akiyama T., Inoue J., Matsumoto K., Sudo K., Azuma M.,
  • Journal Title: Plos One Volume: 6 Issue: 4 Pages: 18404-18404
  • DOI: 10.1371/journal.pone.0018404
  • Peer Reviewed
• [Journal Article] IL-33 and Airway Inflammation (2011)
  • Author(s): Oboki, K, Nakae, S, Matsumoto K, Saito, H
  • Journal Title: Allergy Asthma Immunol Res Volume: 3(2) Issue: 2 Pages: 81-8
  • DOI: 10.4168/aair.2011.3.2.81
  • Peer Reviewed
• [Journal Article] 多層的疾患オミックス研究 (2011)
  • Author(s): 大保木啓介、松本健治、斎藤博久
  • Journal Title: 医療(Japanese journal of National Medical Services) Volume: 65(3) Pages: 135-145
  • NAID: 40018778707
  • Peer Reviewed
• [Journal Article] 喘息表現型の多様性/病態・治療-小児 (2011)
  • Author(s): 大保木啓介、岡田直子、小島令嗣、松本健治、斎藤博久
  • Journal Title: Allergy From the Nose to the Lung Volume: 9(3) Pages: 9-14
• [Journal Article] IL-33 is a crucial amplifier of innate rather than acquired immunity. (2010)
  • Author(s): Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, KiyonariH, Matsumoto K, Sudo K, Okumura K, SaitoH, Nakae S.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 107(43) Issue: 43 Pages: 18581-6
  • DOI: 10.1073/pnas.1003059107
• [Journal Article] Development of IL-17-mediated Delayed-Type Hypersensitivity Is Not Affected by Down-Regulation of IL-25 Expression (2010)
  • Author(s): Ishii A, Oboki K, Nambu A, Morita H, OhnoT, Kajiwara N, Arae K, Sudo H, Okumura K, Saito H, Nakae S.
  • Journal Title: Allergology International Volume: 59 Issue: 4 Pages: 399-408
  • DOI: 10.2332/allergolint.10-OA-0218
  • NAID: 10029671236
  • ISSN: 1323-8930, 1440-1592
• [Journal Article] Amphiregulin is Not Essential for Induction of Contact Hypersensitivity (2010)
  • Author(s): Yagami A, Oboki, K,(3番目) Saito, H,(9番目) Nakae, S.(last), et al
  • Journal Title: Allergology International Volume: 59 Issue: 3 Pages: 277-284
  • DOI: 10.2332/allergolint.09-OA-0149
  • NAID: 10029670767
  • ISSN: 1323-8930, 1440-1592
• [Journal Article] Amphiregulin Is Not Essential for Ovalbumin-Induced Acute Airway Inflammation in Mice (2010)
  • Author(s): Kajiwara N, Oboki, K, Ohno T, Ishii A, Sunnarborg SW, Okumura K, Saito, H, Nakae, S
  • Journal Title: Allergology International Volume: 59 Issue: 2 Pages: 207-211
  • DOI: 10.2332/allergolint.09-OA-0144
  • NAID: 130004477087
  • ISSN: 1323-8930, 1440-1592
• [Journal Article] IL-33 and IL-33 Receptors in Host Defense and Diseases (2010)
  • Author(s): Oboki, K, Ohno T, Kajiwara N, Saito, H, Nakae, S
  • Journal Title: Allergology International Volume: 59 Issue: 2 Pages: 143-160
  • DOI: 10.2332/allergolint.10-RAI-0186
  • NAID: 130004477080
  • ISSN: 1323-8930, 1440-1592
• [Journal Article] IL-33 and IL-33 receptors in host defense and diseases. (2010)
  • Author(s): Oboki K, Ohno T, Kajiwara N, Saito H, Nakae S.
  • Journal Title: Allergol Int. Volume: 59(2) Pages: 143-160
  • Peer Reviewed
• [Journal Article] Amphiregulin is not essential for ovalbumin-induced acute airway inflammation in mice. (2010)
  • Author(s): Kajiwara N, Oboki K, Ohno T, Ishii A, Sunnarborg SW, Okumura K, Saito H, Nakae S.
  • Journal Title: Allergol Int. Volume: 59(2) Pages: 207-211
  • Peer Reviewed
• [Journal Article] Amphiregulin is not essential for induction of contact hypersensitivity. (2010)
  • Author(s): Yagami A, Kajiwara N, Oboki K, Ohno T, Morita H, Sunnarborg SW, Okumura K, Ogawa H, Saito H, Nakae S.
  • Journal Title: Allergol Int. Volume: 59(3) Pages: 277-284
  • Peer Reviewed
• [Journal Article] Development of IL-17-mediated delayed-type hypersensitivity is not affected by down-regulation of IL-25 expression. (2010)
  • Author(s): Ishii A, Oboki K, Nambu A, Morita H, Ohno T, Kajiwara N, Arae K, Sudo H, Okumura K, Saito H, Nakae S.
  • Journal Title: Allergol Int. Volume: 59(4) Pages: 1-20
  • Peer Reviewed
• [Journal Article] IL-33 is a crucial amplifier for innate rather than acquired immunity. (2010)
  • Author(s): Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Abe T, Kiyonari H, Sudo K, Okumura K, Saito H, Nakae S.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 107(43) Pages: 18581-18586
  • Peer Reviewed
• [Presentation] IL-33 in airway inflammation (2011)
  • Author(s): 大保木啓介
  • Organizer: APAPARI 2010 & 第48回JASPACI(第16回アジア太平洋小児アレルギー呼吸器免疫学会、第48回日本小児アレルギー学会合同大会)
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-29
• [Book] 粘膜における自然免疫:マスト細胞・好酸球・好塩基球、臨床粘膜免疫 (2010)
  • Author(s): 斎藤博久,大保木啓介,中江進,烏山一
  • Publisher: シナジー、東京