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Mechanisms for allergen-induced airway inflammation regulated by non-adoptive immune system.

Research Project

Project/Area Number 22790951
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionNational Research Institute for Child Health and Development

Principal Investigator

OBOKI Keisuke  独立行政法人国立成育医療研究センター, 免疫アレルギー研究部, 上級研究員 (80415108)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsサイトカイン / 喘息 / IL-33 / アレルギー
Research Abstract

Our results suggest that allergen Der f 1 or papain induce airway inflammation solely by its protease activity in the rapid time course.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report

Research Products

(19 results)

All 2012 2011 2010

All Journal Article Presentation Book

  • [Journal Article] ST2 Requires Th2-, but Not Th17-, Type Airway Inflammation in Epicutaneously Antigen-Sensitized Mice2012

    • Author(s)
      Morita H, Arae K, Ohno T, Kajiwara N, Oboki, K, Matsuda A, Suto H, Okumura K, Sudo K, Takahashi T, Matsumoto K, Nakae, S
    • Journal Title

      Allergol. Int.

      Volume: 61(2) Issue: 2 Pages: 265-273

    • DOI
      10.2332/allergolint.11-OA-0379
    • NAID
      130004477129
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of Mast Cells and Basophils in IgE Responses and in Allergic Airway Hyperresponsiveness.2012

    • Author(s)
      Sawaguchi, M.
    • Journal Title

      J. Immunol.

      Volume: 188 Pages: 1809-18

    • DOI
      10.4049/jimmunol.1101746
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cimetidine Enhances Antigen-Specific IgE and Th2 Cytokine Production2011

    • Author(s)
      Arae K, Oboki, K, Ohno T, Hirata M, Nakae, S, Taguchi H, Saito, H, Nakajima T
    • Journal Title

      Allergol. Int.

      Volume: 60(3) Issue: 3 Pages: 339-344

    • DOI
      10.2332/allergolint.10-OA-0255
    • NAID
      130004723046
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Paracrine IL-33 enhances lipoplysaccharide-mediated macrophage activation2011

    • Author(s)
      Ohno T., Oboki K., Kajiwara N., Tanaka S., Ikeda M., Iikura M., Akiyama T., Inoue J., Matsumoto K., Sudo K., Azuma M.,
    • Journal Title

      PLoS ONE

      Volume: 6 Pages: 18404-18404

    • DOI
      10.1371/journal.pone.0018404
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-33 and airway inflammation2011

    • Author(s)
      Oboki, K, Nakae, S, Matsumoto K, Saito, H
    • Journal Title

      Allergy, Asthma & Immunology Research

      Volume: 3(2) Pages: 81-8

    • DOI
      10.4168/aair.2011.3.2.81
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 多層的疾患オミックス研究2011

    • Author(s)
      大保木啓介、松本健治、斎藤博久
    • Journal Title

      医療(Japanese journal of National Medical Services)

      Volume: 65(3) Pages: 135-145

    • NAID
      40018778707
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 喘息表現型の多様性/病態・治療-小児2011

    • Author(s)
      大保木啓介、岡田直子、小島令嗣、松本健治、斎藤博久
    • Journal Title

      Allergy From the Nose to the Lung

      Volume: 9(3) Pages: 9-14

    • Related Report
      2011 Annual Research Report
  • [Journal Article] IL-33 is a crucial amplifier of innate rather than acquired immunity2010

    • Author(s)
      Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, KiyonariH, Matsumoto K, Sudo K, Okumura K, SaitoH, Nakae S.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 107(43) Pages: 18581-6

    • DOI
      10.1073/pnas.1003059107
    • Related Report
      2011 Final Research Report
  • [Journal Article] Development of IL-17-mediated Delayed-Type Hypersensitivity Is Not Affected by Down-Regulation of IL-25 Expression2010

    • Author(s)
      Ishii A, Oboki K, Nambu A, Morita H, OhnoT, Kajiwara N, Arae K, Sudo H, Okumura K, Saito H, Nakae S.
    • Journal Title

      Allergol. Int.

      Volume: 59(4)7 Issue: 4 Pages: 399-408

    • DOI
      10.2332/allergolint.10-OA-0218
    • NAID
      10029671236
    • Related Report
      2011 Final Research Report
  • [Journal Article] Amphiregulin is Not Essential for Induction of Contact Hypersensitivity2010

    • Author(s)
      Yagami A, Oboki, K,(3番目) Saito, H,(9番目) Nakae, S.(last), et al
    • Journal Title

      Allergol. Int.

      Volume: 59(3) Issue: 3 Pages: 277-284

    • DOI
      10.2332/allergolint.09-OA-0149
    • NAID
      10029670767
    • Related Report
      2011 Final Research Report
  • [Journal Article] Amphiregulin Is Not Essential for Ovalbumin-Induced Acute Airway Inflammation in Mice2010

    • Author(s)
      Kajiwara N, Oboki, K, Ohno T, Ishii A, Sunnarborg SW, Okumura K, Saito, H, Nakae, S
    • Journal Title

      Allergol. Int.

      Volume: 59(2) Issue: 2 Pages: 207-11

    • DOI
      10.2332/allergolint.09-OA-0144
    • NAID
      130004477087
    • Related Report
      2011 Final Research Report
  • [Journal Article] IL-33 and IL-33 Receptors in Host Defense and Diseases2010

    • Author(s)
      Oboki, K, Ohno T, Kajiwara N, Saito, H, Nakae, S
    • Journal Title

      Allergol. Int.

      Volume: 59(2) Issue: 2 Pages: 143-160

    • DOI
      10.2332/allergolint.10-RAI-0186
    • NAID
      130004477080
    • Related Report
      2011 Final Research Report
  • [Journal Article] IL-33 and IL-33 receptors in host defense and diseases.2010

    • Author(s)
      Oboki K, Ohno T, Kajiwara N, Saito H, Nakae S.
    • Journal Title

      Allergol Int.

      Volume: 59(2) Pages: 143-160

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amphiregulin is not essential for ovalbumin-induced acute airway inflammation in mice.2010

    • Author(s)
      Kajiwara N, Oboki K, Ohno T, Ishii A, Sunnarborg SW, Okumura K, Saito H, Nakae S.
    • Journal Title

      Allergol Int.

      Volume: 59(2) Pages: 207-211

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amphiregulin is not essential for induction of contact hypersensitivity.2010

    • Author(s)
      Yagami A, Kajiwara N, Oboki K, Ohno T, Morita H, Sunnarborg SW, Okumura K, Ogawa H, Saito H, Nakae S.
    • Journal Title

      Allergol Int.

      Volume: 59(3) Pages: 277-284

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of IL-17-mediated delayed-type hypersensitivity is not affected by down-regulation of IL-25 expression.2010

    • Author(s)
      Ishii A, Oboki K, Nambu A, Morita H, Ohno T, Kajiwara N, Arae K, Sudo H, Okumura K, Saito H, Nakae S.
    • Journal Title

      Allergol Int.

      Volume: 59(4) Pages: 1-20

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-33 is a crucial amplifier for innate rather than acquired immunity.2010

    • Author(s)
      Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Abe T, Kiyonari H, Sudo K, Okumura K, Saito H, Nakae S.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 107(43) Pages: 18581-18586

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] IL-33 in airway inflammation2011

    • Author(s)
      大保木啓介
    • Organizer
      APAPARI 2010 & 第48回JASPACI(第16回アジア太平洋小児アレルギー呼吸器免疫学会、第48回日本小児アレルギー学会合同大会)
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-29
    • Related Report
      2011 Final Research Report
  • [Book] 粘膜における自然免疫:マスト細胞・好酸球・好塩基球、臨床粘膜免疫2010

    • Author(s)
      斎藤博久,大保木啓介,中江進,烏山一
    • Publisher
      シナジー、東京
    • Related Report
      2011 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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