The analysis of IL-33 inducible Th17 cells in allergic airway inflammation

• Project/Area Number: 22790952
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: OHNO Tatsukuni 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (80435635)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: IL-33 / IL-17 / TH17 / アレルギー性気道炎症 / Th17 / サイトカイン

Research Abstract

IL-33 leads to induction of eosinophilic inflammation in the pulmonary mucosa through the IL-4 and IL-13-dependent pathway in mouse asthma model. Taken together, it is thought be that IL-33 may have crucial role in induction of atopic asthma. It is well known that IL-6 induces Th17 cells differentiation. The development of Th17 cells in regional LNs in IL-33 inhaled IL-6 deficient mice is similar to that in wild type mice. These results suggest a novel mechanism for the IL-6 independent Th17 cells differentiation.

Research Products

• [Journal Article] Th2-, but not Th17-, typeairway inflammation in epicutaneouslyantigen-sensitized mice (2012)
  • Author(s): Morita H, Arae K, Ohno T, Kajiwara N, Oboki K, Matsuda A, Suto H, Okumura K, Sudo K, Takahashi T, Matsumoto K and Nakae S
  • Journal Title: Allergol Int Volume: 61(2) Pages: 265-73
  • Peer Reviewed
• [Journal Article] IL-33と慢性アレルギー炎症 (2012)
  • Author(s): 大野建州、東みゆき、中江進
  • Journal Title: 実験医学 Volume: 30 Pages: 918-925
• [Journal Article] ST2 Requires Th2-, but Not Th17-, Type Airway Inflammation in Epicutaneously Antigen- Sensitized Mice (2012)
  • Author(s): Morita H, Arae K, Ohno T, Kajiwara N, Oboki K, Matsuda A, Suto H, Okumura K, Sudo K, Takahashi T, Matsumoto K, Nakae S
  • Journal Title: Allergol Int Volume: (In Press)
  • NAID: 130004477129
  • Peer Reviewed
• [Journal Article] Paracrine IL-33stimulation enhanceslipopolysaccharide-mediatedmacrophage activation (2011)
  • Author(s): Ohno T, Oboki K, Morita H, Kajiwara N, Arae K, Tanaka S, Ikeda M, Iikura M, Akiyama T, zInoue J, Matsumoto K, SudoK, Azuma M, Okumura K, Kamradt T, Saito H and Nakae S
  • Journal Title: PLoSOne Volume: 11 ; 6(4)
  • Peer Reviewed
• [Journal Article] Cimetidine enhances antigen-specific IgE and Th2 cytokine production (2011)
  • Author(s): Arae K, Oboki K, Ohno T, Hirata M, NakaeS, Taguchi T, Saito H and Nakajima T
  • Journal Title: Allergol Int Volume: 60(3) Pages: 339-44
  • NAID: 130004723046
  • Peer Reviewed
• [Journal Article] Okumura K., Kamradt T., Saito H., Nakae S. Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage (2011)
  • Author(s): Ohno T., Oboki K., Kajiwara N., Tanaka S., Ikeda M., Iikura M., Akiyama T., Inoue J., Matsumoto K., Sudo K., Azuma M.,
  • Journal Title: Plos One Volume: 6 Issue: 4 Pages: 18404-18404
  • DOI: 10.1371/journal.pone.0018404
  • Peer Reviewed
• [Journal Article] Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation. (2011)
  • Author(s): Tatsukuni Ohno
  • Journal Title: Plos One Volume: (In Press)
  • Peer Reviewed
• [Journal Article] IL-33 is a crucialamplifier of innate rather thanacquired immunity (2010)
  • Author(s): Oboki K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, Kiyonari H, Sudo K, Okumura K, Saito Hand Nakae S
  • Journal Title: ProcNatl Acad Sci USA Volume: 107(43) Pages: 18581-6
  • Peer Reviewed
• [Journal Article] IL-33 and IL-33 receptorsin host defense and diseases (2010)
  • Author(s): Oboki K, Ohno T, Kajiwara N, Saito H, and Nakae S
  • Journal Title: Allergol Int Volume: 59(2) Pages: 143-60
  • Peer Reviewed
• [Journal Article] Development of IL-17-mediateddelayed-type hypersensitivity is notaffected by down-regulation of IL-25expression (2010)
  • Author(s): Ishii A, Oboki K, Nambu A, Morita H, Ohno T, Kajiwara N, Arae K, Sudo H, Okumura K, Saito H, and Nakae S
  • Journal Title: Allergol Int Volume: 59(4) Pages: 399-408
  • Peer Reviewed
• [Journal Article] Amphiregulin is not essential forinduction of contact hypersensitivity (2010)
  • Author(s): Yagami A, Kajiwara N, Oboki O, Ohno N, Morita H, Sunnarborg SW, Okumura K, Ogawa H, Saito H, and Nakae S
  • Journal Title: Allergol Int Volume: 59(3) Pages: 25-25
  • NAID: 10029670767
  • Peer Reviewed
• [Journal Article] Amphiregulin is not essentialfor ovalbumin-induced acute airwayinflammation in mice (2010)
  • Author(s): Kajiwara N, Oboki K, Ohno T, Ishii A, Sunnarborg SW, Okumura K, Saito H, and Nakae S
  • Journal Title: Allergol Int. 2010 Volume: 59(2) Pages: 207-11
  • Peer Reviewed
• [Journal Article] 疾患におけるIL-33とIL-33受容体の役割 (2010)
  • Author(s): 大保木啓介、大野建州、梶原直樹、斎藤博久、中江進
  • Journal Title: 実験医学 Volume: 28 Pages: 162-166
• [Journal Article] マスト細胞による免疫調節機序 (2010)
  • Author(s): 大保木啓介、大野建州、梶原直樹、斎藤博久、中江進
  • Journal Title: 臨床免疫・アレルギー科 Volume: 53 Pages: 29-35
• [Journal Article] IL-33 is a crucial amplifier of innate rather than acquired immunity. (2010)
  • Author(s): Keisuke Oboki, Tatsukuni Ohno
  • Journal Title: Proc Natl Acad Sci USA Volume: 107 Pages: 581-586
  • Peer Reviewed
• [Journal Article] IL-33 and IL-33 receptors in host defense and diseases. (2010)
  • Author(s): Keisuke Oboki, Tatsukuni Ohno
  • Journal Title: Allergol Int Volume: 59 Pages: 143-160
  • NAID: 10029670102
  • Peer Reviewed
• [Journal Article] IL-33 and IL-33 receptorsin host defense and diseases (2008)
  • Author(s): Oboki K, Ohno T, Kajiwara N, Saito H, and Nakae S
  • Journal Title: Allegol Int Volume: 57(2) Pages: 121-34
  • Peer Reviewed
• [Presentation] Paracrine IL-33 stimulation enhanceslipopolysaccharide-mediatedmacrophage activation (2011)
  • Author(s): 大野建州、東みゆき、中江進
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] Paracrine IL-33 Stimulation Enhances Lipopolysaccharide-Mediated Macrophage Activation (2011)
  • Author(s): 大野建州、東みゆき、奥村康、中江進
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-27
• [Presentation] IL-33 is acrucial amplifier of innate ratherthan acquired immunity (2011)
  • Author(s): 大保木啓介、大野建州、梶原直樹、新江賢、森田英明、石井明奈、南部あや、阿部高也、清成寛、松本健治、須藤カツ子、奥村康、斎藤博久、中江進
  • Organizer: 第20回東京免疫フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2011-02-22
• [Presentation] IL-33 is a crucial amplifier of innate rather than acquired immunity. (2011)
  • Author(s): 大野建州
  • Organizer: 東京免疫フォーラム
  • Place of Presentation: 東京大学医科学研究所(東京都)
  • Year and Date: 2011-02-22
• [Presentation] Paracrine IL-33 stimulation enhanceslipopolysaccharide-mediatedmacrophage activation (2011)
  • Author(s): Ohno T, Azuma M, Nakae S
  • Organizer: 98th AAIAnnual Meeting, American Associationof Immunologists, Immunology 2011
  • Place of Presentation: San Francisco, USA
• [Book] 疾患モデルの作製と利用-免疫疾患 (2011)
  • Author(s): 大野建州、中江進
  • Publisher: エル・アイ・シー
• [Book] モデル動物利用マニュアル、IL-33/IL-33R(ST2) (2011)
  • Author(s): 大野建州
  • Publisher: LIC(印刷中)