Epigenetic gene regulation in sepsis
| Project/Area Number |
22790956
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Infectious disease medicine
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| Research Institution | Keio University |
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Principal Investigator |
ISHII Makoto 慶應義塾大学, 医学部, 特任助教 (30317333)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 敗血症 / エピジェネティクス |
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| Research Abstract |
We evaluated the epigenetic gene regulation in mice model of polymicrobial sepsis. The peritoneal macrophages recovered from septic mice showed M2 phenotype and was regulated by histone modification. CXCR2 levels in peripheral neutrophils recovered from septic mice were also regulated by epigenetic change, contributing to worsening the severity of sepsis. In addition, we showed the importance of MLL, a histone H3K4 methyltransferase, during sepsis.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Carbon black nanoparticles enhance bleomycin-induced lung inflammatory and fibrotic changes in mice2011
Author(s)
Kamata H, Tasaka S, Inoue K, Miyamoto K, Nakano Y, Shinoda H, Kimizuka Y, Fujiwara H, Ishii M, Hasegawa N, Takamiya R, Fujishima S, Takano H, Ishizaka A
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Journal Title
Exp Biol Med
Volume: 236
Pages: 315-324
Related Report
Peer Reviewed
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[Journal Article] The post sepsis-induced expansion and enhanced function of regulatory T cells creates an environment to potentiate tumor growth2010
Author(s)
Cavassani CA, Wen H, Moreira AP, Schaller MA, Carson IV WF, Ishii M, Lindell DM, Lukacs NW, Keshamouni WG, Hogaboam CM, Kunkel SL
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Journal Title
Blood
Volume: 115
Pages: 4403-4411
Related Report
Peer Reviewed
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