Research Project
Grant-in-Aid for Young Scientists (B)
We demonstrated that galactosylceramide, the activator of NKT cells, has an antiviral effect in HBV-Tg mice established as the experimental model for the chronic HBV infection. We also showed that polyIC with hepatotropic properties activates innate immune response, resulting in antiviral effect in HBV-infected chimeric mice with human livers. These results suggest the possibility that activation of innate immune response leads to the novel therapeutic approaches against the chronic HBV infection.Further, we found that chronic HBV infection suppresses humoral factors from livers which are essential for maintaining immune cells by gene expression analysis using the next generation sequencer. This suppression of humoral factors caused the apoptosis of immune cells in livers. This result suggests the new mechanism of the chronicity of HBV infection, which leads to invent the new therapy.
All 2012 2011 2010 Other
All Journal Article (10 results) (of which Peer Reviewed: 8 results) Presentation (14 results) Remarks (3 results)
Sci Rep.
Volume: 2 Pages: 259-259
Scientific Reports
Volume: 2 Issue: 1 Pages: 259-259
10.1038/srep00259
肝胆膵
Volume: 63 Pages: 1087-1094
J Infect Dis.
Volume: 204(8) Pages: 1172-80
J. Hepatology
Volume: 55 Pages: 512-521
Journal of Infectious Diseases
Volume: 204 Pages: 1172-1180
J Virol.
Volume: 84(22) Pages: 11761-70
Volume: 61 Pages: 216-222
Journal of Virology
Volume: 84 Pages: 11761-11770
Journal of hepatology
Volume: (In press)
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