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Characterization of a novel HIV-2 circulating recombinant form CRF01_AB

Research Project

Project/Area Number 22790962
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Infectious disease medicine
Research InstitutionNational Hospital Organization Nagoya Medical Center

Principal Investigator

IBE Shiro  独立行政法人国立病院機構(名古屋医療センター臨床研究センター), 感染・免疫研究部, 研究員 (10399595)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsウイルス / 感染症
Research Abstract

Viral production of HIV-2 CRF01_AB isolates was 10-to 100-fold higher than that of HIV-2 group A and B isolates. Furthermore, a severe cytopathic effect was observed in HIV-2 CRF01_AB-infected cells. As the findings would explain in part the high pathogenicity of HIV-2 CRF01_AB, further detailed characterization of the virus would be the next important study.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (20 results)

All 2011 2010

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (12 results)

  • [Journal Article] Cellular HIV-1 DNA levels in patients receiving antiretroviral therapy strongly correlate with therapy initiation timing but not with therapy duration2011

    • Author(s)
      Watanabe D, Ibe S, Uehira T, Minami R, Sasakawa A, Yajima K, Yonemoto H, Bando H, Ogawa Y, Taniguchi T, Kasai D, Nishida Y, Yamamoto M, Kaneda T, Shirasaka T.
    • Journal Title

      BMC Infect Dis

      Volume: 11 Issue: 1 Pages: 146-146

    • DOI

      10.1186/1471-2334-11-146

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 世界最初のHIV-2組換え流行株CRF01_ABの発見2011

    • Author(s)
      伊部史朗
    • Journal Title

      日本エイズ学会誌

      Volume: 13 Pages: 76-82

    • NAID

      10031161805

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Clinical significance of HIV reverse-transcriptase inhibitor-resistance mutations2011

    • Author(s)
      Ibe S, Sugiura W.
    • Journal Title

      Future Microbiol

      Volume: 6 Issue: 3 Pages: 295-315

    • DOI

      10.2217/fmb.11.7

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outbreak of hepatitis B virus genotypeA and transmission of genetic drug resistance in cases coinfected with HIV-1 in Japan2011

    • Author(s)
      Fujisaki S, Yokomaku Y, Shiino T, Koibuchi T, Hattori J, Ibe S, Iwatani Y, Iwamoto A, Shirasaka T, Hamaguchi M, Sugiura W
    • Journal Title

      J. Clin. Microbiol

      Volume: 49 Issue: 3 Pages: 1017-1024

    • DOI

      10.1128/jcm.02149-10

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Outbreak of hepatitis B virus genotype A and transmission of genetic drug resistance incases coinfected with HIV-1 in Japan2011

    • Author(s)
      Fujisaki S, Yokomaku Y, Shiino T, Koibuchi T, Hattori J, Ibe S, Iwatani Y, Iwamoto A, Shirasaka T, Hamaguchi M, Sugiura W
    • Journal Title

      J Clin Microbiol

      Volume: 49 Pages: 1017-1024

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trends in transmitted drug-resistant HIV-1 and demographic characteristics of newly diagnosed patients : nationwide surveillance from 2003 to 2008 in Japan2010

    • Author(s)
      Hattori J, Shiino T, Gatanaga H, Yoshida S, Watanabe D, Minami R, Sadamasu K, Kondo M, Mori H, Ueda M, Tateyama M, Ueda A, Kato S, Ito T, Oie M, Takata N, Hayashida T, Nagashima M, Matsuda M, Ibe S, Ota Y, Sasaki S, Ishigatsubo Y, Tanabe Y, Koga I, Kojima Y, Yamamoto M, Fujita J, Yokomaku Y, Koike T, Shirasaka T, Oka S, Sugiura W.
    • Journal Title

      Antiviral Res

      Volume: 88 Issue: 1 Pages: 72-79

    • DOI

      10.1016/j.antiviral.2010.07.008

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HIV-2 CRF01_AB : first circulating recombinant form of HIV-22010

    • Author(s)
      Ibe S, Yokomaku Y, Shiino T, Tanaka R, Hattori J, Fujisaki S, Iwatani Y, Mamiya N, Utsumi M, Kato S, Hamaguchi M, Sugiura W.
    • Journal Title

      J. AIDS

      Volume: 54 Issue: 3 Pages: 241-247

    • DOI

      10.1097/qai.0b013e3181dc98c1

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 本邦におけるHIV-2の疫学動向と新たな組換え流行株CRF01_ABの同定2010

    • Author(s)
      伊部史朗、横幕能行、杉浦亙
    • Journal Title

      病原微生物検出情報

      Volume: 31 Pages: 232-233

    • URL

      http://idsc.nih.go.jp/iasr/31/366/dj3664.html

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Drug-resistance profiles of HIV-2 CRF01_AB-infected case during abacavir+lamivudine+lopinavir/r therapy2011

    • Author(s)
      Ibe S, Yokomaku Y, Maejima M, Iwatani Y, Sugiura W
    • Organizer
      6th German-Japanese HIV Symposium
    • Place of Presentation
      Bochum, Germany
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Identification of novel drug-resistance mutations selected during abacavir+lamivudine+lopinavir/r therapy in HIV-2 CRF01_AB infection2011

    • Author(s)
      Ibe S, Masaoka T, Yokomaku Y, Iwatani Y, Sugiura W
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ウェスタンブロット法によりHIV-1/HIV-2重複感染が疑われた症例の精査解析2011

    • Author(s)
      伊部史朗,近藤真規子,今村淳治,岩谷靖雅,横幕能行,杉浦亙
    • Organizer
      第25回日本エイズ学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 抗レトロウイルス療法中のHIV-2 CRF01_AB感染症例に認めた薬剤耐性変異2011

    • Author(s)
      伊部史朗,正岡崇,横幕能行,岩谷靖雅,杉浦亙
    • Organizer
      第13回白馬シンポジウム
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 抗レトロウイルス治療中のHIV-2 CRF01_AB感染症例に認めた薬剤耐性変異2011

    • Author(s)
      伊部史朗,横幕能行,服部純子,杉浦亙
    • Organizer
      第85回日本感染症学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 抗レトロウイルス療法のモニタリングのためのplasma HIV-2 viral load測定系の確立2010

    • Author(s)
      伊部史朗、横幕能行、服部純子、岩谷靖雅、加藤真吾、杉浦亙
    • Organizer
      第24回 日本エイズ学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 定量PCR法を用いたHIV-2 viral load測定系の確立とその臨床応用2010

    • Author(s)
      伊部史朗、横幕能行、服部純子、杉浦亙
    • Organizer
      第84回 日本感染症学会総会
    • Place of Presentation
      京都
    • Year and Date
      2010-04-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] First case of HIV-2 CRF01_AB infection treated with combination antiretroviral therapy2010

    • Author(s)
      Ibe S, Yokomaku Y, Hattori J, Iwatani Y, Sugiura W.
    • Organizer
      11th Annual Symposium on Antiviral Drug Resistance
    • Place of Presentation
      Hershey, USA
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Development of a highly sensitive and reproducible plasma HIV-2 RNA copy quantification method for monitoring antiretroviral treatment2010

    • Author(s)
      Ibe S, Yokomaku Y, Tanaka R, Hattori J, Fujisaki S, Iwatani Y, Kato S, Hamaguchi M, Sugiura W
    • Organizer
      XVIII International AIDS Conference
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Molecular epidemiology of HIV-2 in Japan : identification of the first circulating recombinant form of HIV-2, CRF01_AB2010

    • Author(s)
      Ibe S, Yokomaku Y, Shiino T, Tanaka R, Hattori J, Fujisaki S, Iwatani Y, Mamiya N, Utsumi M, Kato S, Hamaguchi M, Sugiura W.
    • Organizer
      5th International Workshop on HIV Transmission
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 抗レトロウイルス療法のモニタリングのためのplasma HIV-2 viral load測定系の確立2010

    • Author(s)
      伊部史朗,横幕能行,服部純子,岩谷靖雅,加藤真吾,杉浦亙
    • Organizer
      第24回日本エイズ学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 定量PCR法を用いたHIV-2 viral load測定系の確立とその臨床応用2010

    • Author(s)
      伊部史朗,横幕能行,服部純子,杉浦亙
    • Organizer
      第84回日本感染症学会総会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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