The mechanism of inflammation in autoimmune response during the acute phase of Kawasaki disease.

• Project/Area Number: 22790969
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: University of Toyama
• Principal Investigator: SAITO Kazuyoshi 富山大学, 大学病院, 助教 (30566097)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 川崎病 / マイクロRNA / VEGF-A / 血管炎 / miR-93

Research Abstract

We identified 5 miRs, miR-93, miR-877, miR-92b, miR-182 and miR-296-5p, which were highly specific to the acute phase of Kawasaki disease. In particular miR-93 likely controlled the expression of VEGFA and probably has an important role in pathogenesis.

Research Products

• [Journal Article] 川崎病急性期におけるmiRNAによるNF-kBを中心とした自然免疫応答による炎症の制御機構の解明、厚生労働省研究費補助金、重症川崎病患者に対する免疫グロブリン・ステロイド初期併用投与の効果を検討する前方視的無作為化比較試験 (2011)
  • Author(s): 市田蕗子、齋藤和由
  • Journal Title: 平成22年度研究年度終了報告書 Pages: 60-62
• [Journal Article] 川崎病急性期におけるmiRNAによるNF-kBを中心とした自然免疫応答による炎症の制御機構の解明 (2011)
  • Author(s): 市田蕗子
  • Journal Title: 厚生労働省研究費補助金、重症川崎病患者に対する免疫グロブリン・ステロイド初期併用投与の効果を検討する前方視的無作為化比較試験平成22年度研究年度終了報告書,2011.4 Pages: 60-62
• [Presentation] 急性期川崎病の流血中末梢血単核球細胞におけるマイクロRNAによるmRNAの発現制御の可能性～miR-93によるVEGFAの制御～ (2011)
  • Author(s): 齋藤和由
  • Organizer: 第114回日本小児科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-08-14
• [Presentation] 急性期川崎病の流血中末梢血単核球細胞におけるマイクロRNAによるmRNAの発現制御の可能性 (2011)
  • Author(s): 齋藤和由
  • Organizer: 第75回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2011-08-02
• [Presentation] MicroRNAs May Control MRNA In Circulating PBMCs During The Acute Phase Of Kawasaki Disease (2011)
  • Author(s): Kazuyoshi Saito
  • Organizer: The 45th Annual Meeting for the Association for European pediatric cardiology
  • Place of Presentation: Granada, Spain
  • Year and Date: 2011-05-20
• [Presentation] MicroRNAs May Control MRNA In Circulating PBMCs During The Acute Phase Of Kawasaki Disease (2011)
  • Author(s): Kazuyoshi Saito
  • Organizer: The 45^<th> Annual Meeting for the Associati on for European pediatric cardiology
  • Place of Presentation: Granada, Spain
  • Year and Date: 2011-05-20
• [Presentation] MicroRNAs may control mRNA networks in circulating PBMCs during the acute phase of Kawasaki disease (2010)
  • Author(s): Kazuyoshi Saito
  • Organizer: AHA 2010 Chicago
  • Place of Presentation: McCormick Place