The study of graft-versus-leukemia effect of cord blood NK cells Against refractory childhood leukemia

• Project/Area Number: 22790971
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: University of Yamanashi
• Principal Investigator: OHSHIRO Hiroko 山梨大学, 医学部・附属病院, 助教 (50377537)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: NK細胞 / 急性リンパ性白血病 / 臍帯血移植 / KIRリガンド不一致

Research Abstract

Acute lymphoblastic leukemia(ALL) with 11q23 translocation is associated with an extremely poor prognosis despite intensive chemotherapy and hematopoietic stem cell transplantation(SCT). In recent years, it has been postulated that NK cells can play a role in reducing disease recurrence through GVL(graft-versus leukemia) effect. ALL cells with 11q23 translocation are sensitive to killing by KIR(major NK receptors) ligand incompatible cord blood-NK cells, and therefore the GVL effect against this leukemia could be considerably expected if the KIR ligand incompatible donor is selected for CBT.

Research Products

• [Journal Article] 9;11転座を有するCD10陽性急性リンパ性白血病 (2010)
  • Author(s): 本名(大城)浩子
  • Journal Title: 日本小児血液学会雑誌 Volume: 24巻 Pages: 97-101
  • Peer Reviewed
• [Presentation] 2回目の同種移植7年後にALLの骨髄局所再発を来した1男児例 (2011)
  • Author(s): 大城浩子
  • Organizer: 日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋ベイシア文化ホール
  • Year and Date: 2011-11-27
• [Presentation] 2回目の同種移植7年後にALLの骨髄局所再発を来した1男児例 (2011)
  • Author(s): 大城浩子
  • Organizer: 日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋ベイシア文化ホール(群馬県)
  • Year and Date: 2011-11-27
• [Presentation] Eculizumab treatment followed by U-BMT for a pediatric PNH/AA patient (2011)
  • Author(s): 大城浩子
  • Organizer: 日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-15
• [Presentation] Eculizumab treatment followed by U-BMT for a pediatric PNH/AA patient (2011)
  • Author(s): 大城浩子
  • Organizer: 日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-15
• [Presentation] The cytotoxicity of cord blood NK cells against MLL-rearramged ALL is associated with SNPs of NKG2D (2010)
  • Author(s): 本名(大城)浩子
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-09-24