The role of integrin for pediatric peritoneal sclerosis

• Project/Area Number: 22790985
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: The University of Tokushima
• Principal Investigator: SUGA Kenichi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 非常勤講師 (70511335)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: インテグリン / 腹膜硬化症 / 小児 / 線維化 / 細胞外基質

Research Abstract

The extracellular matrix(ECM) and integrins increased on the encapsulating peritoneal sclerosis(EPS) model rat. ECM proteins and integrins increased when tumor growth factor-β(TGF-β) stimulated the cultured peritoneal fibroblasts. These results suggest that integrins enhanced by TGF-βmight contribute EPS development through the abnormal ECM remodeling.