Analysis of molecular function of CCL8 as a biomarker for acute graft-versus-host disease

Research Project

Project/Area Number	22790990
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Pediatrics
Research Institution	Sapporo Medical University
Principal Investigator	YAMAMOTO Masaki 札幌医科大学, 医学部, 研究員 (80404664)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	移植片対宿主病 / バイオマーカー / ケモカイン / 造血幹細胞移植 / マウスモデル / CCL8
Research Abstract	We studied about chemokine CCL8 as a biomarker of acute graft-versus-host disease(GVHD). The plasma CCL8 concentration in GVHD mouse model showed correlated with the severity and the prognosis of GVHD mice. Similarly, serum CCL8 concentration may reflect the response to the treatment against GVHD and correlate with the severity of GVHD in human.