| Project/Area Number |
22790991
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokyo (2011)
Yokohama City University (2010) |
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Principal Investigator |
HARITA Yutaka 東京大学, 医学部附属病院, 講師 (10451866)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 小児腎 / 泌尿器学 / 蛋白尿 / 糸球体上皮細胞 / スリット膜 / Nephrin / 細胞極性 / aPKC / PAR3 |
|---|
| Research Abstract |
We analyzed how the Par-aPKC polarity complex is involved in the maintenance of slit diaphragm structure, the intercellular junctional complex responsible for the glomerular filtration barrier, and in the downstream signaling pathway. We found that slit diaphragm components are rapidly endocytosed and exocytosed and PAR-aPKC regulates exocytosis of Nephrin. This result unravels the mechanism of formation and maintenance of slit diaphragm, which is necessary for the prevention of proteinuria.
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