Diclofenac enhances proinflammatory cytokine-induced phagocytosis through nitric oxide production in cultured microglia
| Project/Area Number |
22790993
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Nagoya City University |
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Principal Investigator |
KAKITA Hiroki 名古屋市立大学, 大学院・医学研究科, 助教 (40528949)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | インフルエンザ脳症 / グリア細胞 / ジクロフェナック / 一酸化窒素 / ミクログリア / 血液脳関門 / アストロサイト / アクアポリン |
|---|
| Research Abstract |
this study demonstrates that iNOS and NO are induced in microglia cultures by proinflammatory cytokines. The addition of DCF further augments NO production. This effect is mediated via NF-B signaling and induced microglia activity and phagocytosis.
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Report
(3 results)
Research Products
(19 results)
