Mechanism of NLRR1-regulated signaling pathway and establishment of a novel targeted therapy
| Project/Area Number |
22791016
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
TAKATORI Atsushi 千葉県がんセンター(研究所), 小児がん研究センター, 研究員 (40455390)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 小児腫瘍学 / 癌 / シグナル伝達 / NLRR / ノックアウトマウス |
|---|
| Research Abstract |
New and efficient therapeutic strategies are required to improve overall survival for the high-risk neuroblastoma (NB). In the present project, intensive functional analyses have been performed to understand the mechanism of NLRR1-regulated growth signaling pathway. The study demonstrated that NLRR1 enhances proliferative signals rather than differentiating signals through membrane structure of lipid rafts. Functional screening has identified anti-NLRR1 monoclonal antibody harboring growth inhibitory effect, suggesting that a potential therapeutic strategy for NB therapy.
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Report
(4 results)
Research Products
(16 results)
