| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
We reported that CD133 suppressed differentiation in NB cells and CD133 was up-regulated in NB sphere (ONCOGENE, 2011). To identify the sphere specific transcription factors, we examined expression of several transcription factors in NB spheres. The expression pattern of the TFX transcription factor was correlated with that of CD133 during NB tumor sphere formation. Furthermore, TFX directly bound to CD133 promoter region and up-regulated CD133 expression, cell proliferation and NB sphere forming efficiency. These results suggest that tumor sphere specific transcription factor TFX may contribute to maintenance of tumor initiating cells and their characteristics.
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