Development of antiviral treatment for paramyxovirus infection that target the L protein
Project/Area Number |
22791018
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Pediatrics
|
Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
SEKI Fumio 国立感染症研究所, ウイルス第三部, 主任研究官 (20443111)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | 小児感染症 / 麻疹ウイルス / Pタンパク質 / Lタンパク質 / タンパク質発現 |
Research Abstract |
P protein with a deletion of amino acids between 307 and 336 (Pd307-336) decreased the interaction between P and P, and P and L protein. Expressing the Pd307-336 inhibited the virus growth. Similar effects were obtained when lacking the N-terminal amino acids of the Pd307-336. I was expressed L protein and mutant P proteins using Escherichia coli as a host.
|
Report
(4 results)
Research Products
(3 results)