| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
We performed molecular analysis on 140 patients with Prader-Willi syndrome. Here, we report that advanced maternal age was a risk factor for the development of PWS due to upd(15) mat resulting from meiosis I error, and that relative frequency of upd(15) mat due to trisomy rescue after non-disjunction during meiosis I was increased since 2003 when advanced maternal age became obvious in Japan. We also repot that the frequency of births after ART was significantly higher in PWS patients than in the general population. These results showed that ART and/or ART-related parental factors(maternal age etc.) can be a risk factor for PWS in general.
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