The effect of HGF on MMP-9 expression in human meningeal cells; Toward the development of novel therapeutic strategies for posthemorrhagic hydrocephalus

Research Project

Project/Area Number	22791024
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Embryonic/Neonatal medicine
Research Institution	Asahikawa Medical College
Principal Investigator	OKAMOTO Toshio 旭川医科大学, 医学部, 助教 (20431405)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	脳室内出血 / 出血後水頭症 / HGF / TGF-betal / MMP-9 / ヒト髄膜細胞 / TGF-beta1 / Hepatocyte growth factor / Matrix metalloproteinase-9 / c-Met
Research Abstract	We treated cultured human meningeal cells with human recombinant HGF and TGF-beta1. We found that the expression of MMP-9 was enhanced by HGF, most probably through the activation of the ERK1/2 and PI3K signaling pathways. And more, we found that TGF-beta1 enhances the effect of HGF on MMP-9 expression in human meningeal cells. Our present data may provide an impetus for the development of therapies targeting MMP-9 or HGF, which will eliminate the need for a shunt operation in PHH patients.

Report

(4 results)