Analysis of magnetic resonance imaging in cerebral white matter injury using chronically instrumented fetal sheep

• Project/Area Number: 22791025
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Tohoku University
• Principal Investigator: AKIYAMA Shizuko 東北大学, 病院, 助手 (80466549)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥5,460,260 (Direct Cost: ¥4,200,200、Indirect Cost: ¥1,260,060); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥1,430,260 (Direct Cost: ¥1,100,200、Indirect Cost: ¥330,060); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 胎児 / 脳白質損傷 / 脳室周囲白質軟化 / MRI / 診断基準

Research Abstract

We analyzed the magnetic resonance imaging (MRI) in the cerebral white matter injury (WMI) using chronically instrumented fetal sheep, suffered from ischemia and/or inflammation in utero. Abnormal MRI signals were found in 5 fetuses induced focal WMI while unexpectedly also found in 3 fetuses not induced WMI, as a focal low T1, diffuse high T2 or focal high T1 /low T2 intensity. It might be possible that these abnormal signals observed in the latter group reflected histologic changes in acute phase of diffuse WMI, clinically more important than focal WMI. Consequently, it would be necessary to be evaluated the oligodendroglial development in the white matter by adding the immuno-histochemical analysis as a next step.

Research Products

• [Journal Article] バゾプレッシンの循環器系に及ぼす影響 (2013)
  • Author(s): 松田直,加賀麻衣子,臼田治夫,伊藤智子,渡邊真平,小野寺幸子,新関昌枝,秋山志津子,北西隆太,渡邉達也
  • Journal Title: 日本周産期・新生児医学会雑誌 Volume: 49inpress
  • NAID: 10031176875
  • URL: http://www.jspnm.com/Gakkaishi/mokuji.aspx
• [Journal Article] バゾプレッシンの循環器系に及ぼす影響 (2013)
  • Author(s): 松田 直，加賀麻衣子，臼田治夫，伊藤智子，渡邊真平，小野寺幸子，新関昌枝，秋山志津子，北西隆太，渡邉達也．
  • Journal Title: 日本周産期・新生児医学会雑誌 Volume: 49
  • NAID: 10031176875
• [Journal Article] 胎児期に心房粗動と診断され早期娩出した低出生体重児の一例 (2011)
  • Author(s): 新田恩,松田直,井上若葉,荒井那津子,渡辺真平,秋山志津子,北西龍太,渡辺達也,田澤星一,柿崎秀平
  • Journal Title: 周産期医学 Volume: 41 Pages: 1222-5
  • URL: http://www.tokyo-igakusha.co.jp/f/b/index/zc01/6/oa_table/b_z_top.html
  • Peer Reviewed
• [Journal Article] 胎児・新生児期における生物時計と光環境の重要性 (2011)
  • Author(s): 渡辺真平,秋山志津子,太田英伸
  • Journal Title: 睡眠医療 Volume: 5 Pages: 51-8
  • URL: http://www.lifesci.co.jp/cgi-bin/search/periodicals.cgi?type=sleep
• [Journal Article] 胎児・新生児期における生物時計と光環境の重要性 (2011)
  • Author(s): 渡邊真平, 秋山志津子, 太田英伸
  • Journal Title: 睡眠医療 Volume: 5 Pages: 51-58
  • Peer Reviewed
• [Journal Article] 胎児期に心房粗動と診断され早期娩出した低出生体重児の一例 (2011)
  • Author(s): 新田恩, 松田直, 井上若葉, 荒井那津子, 渡辺真平, 秋山志津子, 北西龍太, 渡辺達也, 田澤星一, 柿崎秀平
  • Journal Title: 周産期医学 Volume: 41 Pages: 1222-1225
  • Peer Reviewed
• [Journal Article] The Uterus Sustains Stable Biological Clock during Pregnancy (2010)
  • Author(s): Akiyama S, Ohta H, Watanabe S, Moriya T, Hariu A, Nakahata N, Chisaka H, Matsuda T, Kimura Y, Tsuchiya S, Tei H, Okamura K, Yaegashi N.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 221 Issue: 4 Pages: 287-298
  • DOI: 10.1620/tjem.221.287
  • NAID: 130004459846
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed