| Budget Amount *help |
¥5,460,260 (Direct Cost: ¥4,200,200、Indirect Cost: ¥1,260,060)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,430,260 (Direct Cost: ¥1,100,200、Indirect Cost: ¥330,060)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We analyzed the magnetic resonance imaging (MRI) in the cerebral white matter injury (WMI) using chronically instrumented fetal sheep, suffered from ischemia and/or inflammation in utero. Abnormal MRI signals were found in 5 fetuses induced focal WMI while unexpectedly also found in 3 fetuses not induced WMI, as a focal low T1, diffuse high T2 or focal high T1 /low T2 intensity. It might be possible that these abnormal signals observed in the latter group reflected histologic changes in acute phase of diffuse WMI, clinically more important than focal WMI. Consequently, it would be necessary to be evaluated the oligodendroglial development in the white matter by adding the immuno-histochemical analysis as a next step.
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