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Development of a circuit with a high-performance membranous oxygenator for using an artificial placenta in a premature lamb model

Research Project

Project/Area Number 22791026
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Embryonic/Neonatal medicine
Research InstitutionTohoku University

Principal Investigator

WATANABE Shinpei  東北大学, 大学院・医学系研究科, 非常勤講師 (70509413)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords人工胎盤 / 人工羊水 / 人工子宮 / 胎児循環 / 膜型人工肺 / 動脈管 / マイクロスフェア法
Research Abstract

Because previous studies aimed at developing an artificial placenta have had limited success, we hypothesized that the introduction of a high-performance membranous oxygenator to a pumpless artificial placenta could prolong the survival time of premature lambs. Immediately after the delivery of the fetuses, the umbilical vessels were cannulated and connected to the pumpless artificial placenta. Both the fetuses and the circuit were submerged in a warm saline bath. Five fetuses survived for 18. 2 ± 3. 2 (mean ± SEM)hours after attachment to the artificial placenta, which maintained the fetal circulation. We prolonged the survival of fetal lambs using a high-performance membranous oxygenator with a small priming volume.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (2 results) Book (1 results)

  • [Journal Article] 臍帯炎.胎児死亡と胎盤病理2011

    • Author(s)
      加賀麻衣子, 松田直, 渡辺達也, 小野寺幸子, 渡邊真平, 臼田治夫, 八重樫伸生
    • Journal Title

      産科と婦人科

      Volume: 78 Pages: 720-726

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 胎児・新生児期における生物時計と光環境の重要性2011

    • Author(s)
      渡邊真平, 秋山志津子, 太田英伸
    • Journal Title

      睡眠医療

      Volume: 5 Pages: 51-58

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 胎児期に心房粗動と診断され早期娩出した低出生体重児の一例2011

    • Author(s)
      新田恩, 松田直, 井上若葉, 荒井那津子, 渡辺真平, 秋山志津子, 北西龍太, 渡辺達也, 田澤星一, 柿崎秀平
    • Journal Title

      周産期医学

      Volume: 41 Pages: 1222-1225

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The uterus sustains stable biological clock during pregnancy.2010

    • Author(s)
      Akiyama S, Ohta H, Watanabe S, Moriya T, Hariu A, Nakahata N, Chisaka H, Matsuda T, Kimura Y, Tsuchiya S, Tei H, Okamura K, Yaegashi N.
    • Journal Title

      Tohoku J Exp Med

      Volume: 221 Pages: 287-98

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒツジ胎仔を用いた人工胎盤の基礎的検討2011

    • Author(s)
      三浦雄一郎, 松田直, 埴田卓志, 北西龍太, 渡辺真平, 斉藤昌利, 三本木慧介
    • Organizer
      第48回日本人工臓器学会
    • Place of Presentation
      仙台
    • Year and Date
      2011-11-19
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Development of an artificial placenta : Pumplessarteriovenous extracorporeal life support in a premature lamb model2011

    • Author(s)
      Yuichiro Miura, Tadashi Matsuda, Masatoshi Saito, Shinpei Watanabe, Ryuta Kitanishi, Takushi Hanita, Tatsuya Watanabe, Nobuo Yaegashi
    • Organizer
      39th Annual Meeting of the Fetal and Neonatal Physiological Society 2011
    • Place of Presentation
      Palm Cove, Cairns, AU
    • Year and Date
      2011-07-11
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Book] 早産児・新生児の体内時計と新生児室における光環境の設計.「体内時計の科学と産業応用」2011

    • Author(s)
      渡邊真平, 太田英伸
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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