| Project/Area Number |
22791030
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SAKATA Hiromi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (50294666)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 概日リズム / 深部体温 / 脳発達 / 同調因子 / ラット / 視交叉上核 / Per1 |
|---|
| Research Abstract |
To discuss the mechanism of the transition of circadian rhythm from immature to mature shape, we assessed the circadian rhythm of deep body temperature and Per1 expression in rat pups. The timing of suckling acutely affected pup' s body temperature, and the daily rhythm of Per1 expression in the SCN of pups entrained the timing of suckling(or food intake), as well as that in the liver, but not like that in the adult SCN. Thus, we concluded that the timing of suckling(or food intake) is a more important zeitgeber for the pup' s SCN than light/ dark condition. Rats, which inverted SCN rhythm by restriction of feeding time during the postnatal period, showed a significant increase in body weight, hyperactivity, and delayed entrainment with the light/ dark cycle.
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