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Role of dams and light as a zeitgeber during brain development

Research Project

Project/Area Number 22791030
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Embryonic/Neonatal medicine
Research InstitutionThe University of Tokushima

Principal Investigator

SAKATA Hiromi  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (50294666)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords概日リズム / 深部体温 / 脳発達 / 同調因子 / ラット / 視交叉上核 / Per1
Research Abstract

To discuss the mechanism of the transition of circadian rhythm from immature to mature shape, we assessed the circadian rhythm of deep body temperature and Per1 expression in rat pups. The timing of suckling acutely affected pup' s body temperature, and the daily rhythm of Per1 expression in the SCN of pups entrained the timing of suckling(or food intake), as well as that in the liver, but not like that in the adult SCN. Thus, we concluded that the timing of suckling(or food intake) is a more important zeitgeber for the pup' s SCN than light/ dark condition. Rats, which inverted SCN rhythm by restriction of feeding time during the postnatal period, showed a significant increase in body weight, hyperactivity, and delayed entrainment with the light/ dark cycle.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (5 results)

All 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Alteration in anxiety-related behaviours and reduction of serotonergic neurons in raphe nuclei in adult rats prenatally exposed to ethanol2010

    • Author(s)
      K Ohta, H Sakata-Haga, Y Fukui
    • Journal Title

      Cong Anom

      Volume: 50 Pages: 105-114

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 哺乳・育仔リズムが仔の概日リズムに及ぼす影響2011

    • Author(s)
      坂田ひろみ
    • Organizer
      第66回日本解剖学会中国四国支部学術集会
    • Place of Presentation
      徳島大学(徳島市)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 哺乳.育仔リズムが仔の概日リズムに及ぼす影響2011

    • Author(s)
      坂田ひろみ、他4名
    • Organizer
      日本解剖学会第66回中国四国支部学術集会
    • Place of Presentation
      徳島大学(徳島市)
    • Related Report
      2011 Final Research Report
  • [Presentation] Application of ex vivo MRI for non-invasive detection of gross malformations in the rat brain2011

    • Author(s)
      坂田ひろみ、他4名
    • Organizer
      第116回日本解剖学会総会・全国学術集会
    • Place of Presentation
      横浜で開催予定だったが、震災のため誌上開催に変更
    • Related Report
      2011 Final Research Report
  • [Presentation] Application of ex vivo MRI for non-invasive detection of gross malformations in the rat brain2011

    • Author(s)
      Hiromi Sakata-Haga, et al
    • Organizer
      第116回日本解剖学会全国学術集会
    • Place of Presentation
      (震災のため誌上開催)
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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