|Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Transient abnormal myelopoiesis (TAM) occurs in infants with Down syndrome. While most TAM patients ha ve a favorable clinical course, early death occurs in some patients. The main causes of death are organ failure, particularly hepatic failure due to hepatic fibrosis. The involvement of some growth factors and cytokines in the development of hepatic fibrosis was suspected. We investigated the association of circulating chemokines and TGF-β1 with TAM. Serum CCL2 levels were higher in infants with liver failure than in those without. CCL2 might affect the development of liver fibrosis.