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The analysis of serum cytokine and transcription factor level on the pathophysiology of neonatal asphyxia and intraventricular hemorrhage of extremely low birth weight infant

Research Project

Project/Area Number 22791036
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Embryonic/Neonatal medicine
Research InstitutionJichi Medical University

Principal Investigator

KOIKE Yasunori  自治医科大学, 医学部, 助教 (00382903)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords新生児 / 新生児仮死 / 脳室内出血 / サイトカイン / 超低出生体重児 / インドメタシン / 転写因子
Research Abstract

We analyzed cytokine levels in peripheral blood from 5 full-term and 3 preterm infants with neonatal asphyxia and those from 5 full-term and 4 preterm infants without neonatal asphyxia on 0,1,2,3 day of life. We found that inflammatory cytokines were at higher level in the former group and decreased over time.
In peripheral blood from 15 extremely low birth weight (ELBW) infants who received indomethacin for preventing intraventricular hemorrhage and 11 ELBW who did not receive indomethacin, we analyzed cytokine profiles on 0,1,2,3,7,14 day of life. Inflammatory cytokines are at lower levels and decreased over time in the former group than the later group. It suggests that indomethacin inhibits production of these inflammatory cytokines, and preventing a intraventricular hemorrhage.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (3 results)

All 2014 2012 Other

All Presentation (3 results)

  • [Presentation] CAM群とPIH群における超低出生体重児の生後2週間のサイトカインプロファイルの経時的推移2014

    • Author(s)
      小池泰敬、高橋尚人、河野由美、矢田ゆかり、鈴木由芽、西村仁、俣野美雪、桃井真里子
    • Organizer
      第115回日本小児科学会
    • Place of Presentation
      福岡
    • Year and Date
      2014-04-20
    • Related Report
      2011 Final Research Report
  • [Presentation] CAM群および非CAM群における超低出生体重児の生後2週間のサイトカインプロファイルの経時的推移2012

    • Author(s)
      小池泰敬
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-04-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脳室内出血予防インドメタシン投与が超低出生体重児の生後1週間の血中サイトカイン濃度に及ぼす影響の検討

    • Author(s)
      小池泰敬、高橋尚人、河野由美、矢田ゆかり、鈴木由芽、西村仁、俣野美雪、渡部功之、鈴村宏、桃井真里子
    • Organizer
      第48回日本周産期新生児学会
    • Place of Presentation
      埼玉
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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