Basic investigation for treatment of chronic lung disease by G-CSF administration mobilizing of the stem cell to peripheral blood

• Project/Area Number: 22791037
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Keio University
• Principal Investigator: HOKUTO Isamu 慶應義塾大学, 医学部, 助教 (00296625)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 再生医学 / サイトカイン / 再生医療 / 慢性肺疾患 / G-CSF / 造血幹細胞 / 幹細胞

Research Abstract

G-CSF administration significantly improved a mouse model of chronic lung disease. It is unclear whether G-CSF-mobilized peripheral blood stem cells differentiated into pulmonary epithelial cells, whether G-CSF induced the proliferation and differentiatio

Research Products

• [Journal Article] Metabolic acidosis due to continuous drainage of massive chylous pleural effusion in two neonates (2012)
  • Author(s): Okishio E, Arimitsu T, Miwa M,Matsuzaki Y, Hokuto I, Ikeda K
  • Journal Title: Pediatr Int Volume: 54(5) Pages: 732-3
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor levels of cord blood in healthy term newborns. (2012)
  • Author(s): Hokuto I, Matsuzaki Y, Miwa M, ArimitsuT, Okishio E, Ikeda K
  • Journal Title: Arch Dis Child Fetal Neonatal Ed. Volume: 97(5)
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor levels of cord blood in healthy term newborns. (2012)
  • Author(s): Isamu Hokuto
  • Journal Title: Archives of Disease in Childhood Fetal and Neonatal Edition Volume: 97(5) Issue: 5 Pages: 389-389
  • DOI: 10.1136/fetalneonatal-2011-301580
  • Peer Reviewed
• [Journal Article] Surfactant protein A in gastric fluid at birth as a useful marker of differentiation diagnosis between respiratory distress syndrome and transient tachypnea of the newborn (2011)
  • Author(s): Matsuzaki Y, Hokuto I, Ikeda K
  • Journal Title: Pediatr Int Volume: 53(5) Pages: 788-9
  • Peer Reviewed
• [Journal Article] Functional hemispheric specialization in processing phonemic and prosodic auditory changes in neonates (2011)
  • Author(s): Arimitsu T, Uchida-Ota M, Yagihashi T, Kojima S, Watanabe S, Hokuto I, Ikeda K, Takahashi T, Minagawa-Kawai Y
  • Journal Title: Front Psychol Volume: 2 Pages: 202-202
  • Peer Reviewed
• [Journal Article] Usefulness of measurement of urinary N-terminal pro-brain natriuretic peptide in neonatal period (2011)
  • Author(s): Kurihara N, Miwa M, Matsuzaki Y, Hokuto I, Kikuchi H, Katano S, Ikeda K
  • Journal Title: Pediatr Int Volume: 53(4) Pages: 608-608
  • NAID: 10029559422
  • Peer Reviewed
• [Journal Article] Final diagnosis in patients with congenital cystic lung disease detected by fetal ultrasonography (2011)
  • Author(s): Kuratsuji G, Hokuto I, Higuchi M, Koinuma G, Morikawa Y, Hoshino K, Tanaka M, Miyakoshi K, Ikeda K
  • Journal Title: Pediatr Int Volume: 53(1) Pages: 131-2
  • NAID: 10029557469
  • Peer Reviewed
• [Journal Article] Survival of a congenital ileal atresia infant weighing 359 g at birth after laparotomy (2011)
  • Author(s): Fuchimoto Y, Tomita H, Takasato F, Yamamoto Y, Mori M, Shimojima N, Hoshino K, Hokuto I, Ikeda K, Morikawa Y
  • Journal Title: Pediatr Int Volume: 53(1) Pages: 127-8
  • NAID: 10029557456
  • Peer Reviewed
• [Journal Article] C-reactive protein in extremely low birth weight infants using evanescent wave immunoassay to make normative standards after birth (2010)
  • Author(s): Furukawa R, Miwa M, Hokuto I, Ikeda K
  • Journal Title: Pediatr Int Volume: 52(6) Pages: 898-898
  • NAID: 10028184917
  • Peer Reviewed
• [Presentation] distressの無い状態で出生した正期産児の臍帯血血清HGF値 (2012)
  • Author(s): 北東功,松崎陽平, 有光威志, 三輪雅之, 木下眞里, 池田一成
  • Organizer: 第57回日本未熟児新生児学会
  • Place of Presentation: 熊本
  • Year and Date: 2012-11-27
• [Presentation] G-CSF administration improves chronic lung disease caused by exposure tohigh-concentration oxygen in neonatal mice (2012)
  • Author(s): Isamu Hokuto, Takeshi Arimitsu, Yohei Matsuzaki, Kazushige Ikeda
  • Place of Presentation: ウィーン、オーストリア
  • Year and Date: 2012-09-05
• [Presentation] 高濃度酸素投与による慢性肺疾患モデルマウスに対するG‐CSF投与は有効か-第2報- (2012)
  • Author(s): 北東功, 松崎陽平, 有光威志, 三輪雅之, 池田一成
  • Organizer: 第48回日本周産期・新生児医学会総会
  • Place of Presentation: 大宮
  • Year and Date: 2012-07-09
• [Presentation] G-CSF Administration Improves Chronic Lung Disease Caused by Exposure to High-Concentration Oxygen in Neonatal Mice (2012)
  • Author(s): Isamu Hokuto
  • Organizer: European Respiratory Society Annual Meeting in 2012
  • Place of Presentation: Wienna,Austria
• [Presentation] 高濃度酸素投与による慢性肺疾患モデルマウスに対するG-CSF投与は有効か？ -第2報- (2012)
  • Author(s): 北東 功
  • Organizer: 第47回日本周産期・新生児学会総会
  • Place of Presentation: 大宮市、埼玉県
• [Presentation] G-CSF投与は高濃度酸素による肺の気腫化を改善する-第2報- (2012)
  • Author(s): 北東 功
  • Organizer: ２０１２年 慢性肺疾患研究会
  • Place of Presentation: 岡山市、岡山県
• [Presentation] 当院における出生体重400g未満の児へのカルシウムとリンの補給 (2011)
  • Author(s): 北東功, 松崎陽平, 三輪雅之, 有光威志, 置塩英美, 本間英和, 池田一成
  • Organizer: 第56回日本未熟児新生児医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-13
• [Presentation] G-CSF投与は高濃度酸素投与による肺の気腫化を改善する (2011)
  • Author(s): 北東功, 有光威志, 松崎陽平, 三輪雅之, 池田一成
  • Organizer: 第10回慢性肺疾患研究会
  • Place of Presentation: 京王プラザホテル八王子(東京)
  • Year and Date: 2011-10-15
• [Presentation] Association between severe bronchopulmonary dysplasia and serum HGF levels in premature infants during early postnatal life (2011)
  • Author(s): Isamu Hokuto, Takeshi Arimitsu,Masayuki Miwa, Yohei Matsuzaki,Kazushige Ikeda
  • Organizer: European respiratory society annual congress
  • Place of Presentation: アムステルダム、オランダ
  • Year and Date: 2011-09-27
• [Presentation] 高濃度酸素投与による慢性肺疾患モデルマウスに対するG-CSF 投与は有効か? (2011)
  • Author(s): 北東功, 有光威志, 松崎陽平, 三輪雅之, 置塩英美, 池田一成
  • Organizer: 第47回日本周産期・新生児医学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2011-07-11
• [Presentation] 高濃度酸素投与による慢性肺疾患モデルマウスに対するG-CSF投与は有効か? (2011)
  • Author(s): 北東功, 有光威志, 松崎陽平, 三輪雅之, 置塩英美, 池田一成
  • Organizer: 第47回日本周産期・新生児学会総会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2011-07-11
• [Presentation] 血清HGFは慢性肺疾患の重症度予測因子となり得うるか? (2010)
  • Author(s): 北東功、三輪雅之、松崎陽平、有光威志、置塩英美、池田一成
  • Organizer: 第55回日本未熟児新生児学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-07
• [Presentation] 血清HGF は慢性肺疾患の重症度予測因子となりうるか? (2010)
  • Author(s): 北東功, 三輪雅之, 松崎陽平, 有光威志, 置塩英美, 池田一成
  • Organizer: 第55回日本未熟児新生児学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-06