Identification of molecular mechanisms and therapy target in the closure of ductus arteriosus
Project/Area Number |
22791042
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Embryonic/Neonatal medicine
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Research Institution | Kurume University |
Principal Investigator |
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 新生児医学 / 動脈管 / 閉鎖 / 血管内皮 / 新生児 / 遺伝子 |
Research Abstract |
Patent DA accounts for significant morbidity in preterm newborns.Phosphatase and tensin homolog that is a protein phosphatase in PI3 kinase/Akt pathway increases after ductus arteriosus closure. Analysis of the comprehensive gene expression profile changes provided new insight into understanding the mechanism of DA closure
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Ultrasound stimulation restores impaired neovascularization-related capacities of human circulating angiogenic cells2012
Author(s)
Toyama Y, Sasaki K, Tachibana K, Ueno T, Kajimoto H, Yokoyama S, Ohtsuka M, Koiwaya H, Nakayoshi T, Mitsutake Y, Chibana H, Itaya N, Imaizumi T.
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Journal Title
Cardiovasc Res
Volume: 1:95(4)
Issue: 4
Pages: 448-59
DOI
Related Report
Peer Reviewed
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