Identification of molecular mechanisms and therapy target in the closure of ductus arteriosus

• Project/Area Number: 22791042
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kurume University
• Principal Investigator: KAJIMOTO Hidemi 久留米大学, 循環器病研究所, 助教 (50349700)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 新生児医学 / 動脈管 / 閉鎖 / 血管内皮 / 新生児 / 遺伝子

Research Abstract

Patent DA accounts for significant morbidity in preterm newborns.Phosphatase and tensin homolog that is a protein phosphatase in PI3 kinase/Akt pathway increases after ductus arteriosus closure. Analysis of the comprehensive gene expression profile changes provided new insight into understanding the mechanism of DA closure

Research Products

• [Journal Article] Inhibition of eNOS Phosphorylation Mediates Endothelial Dysfunction in Renal Failure : New Effect of Asymmetric Dimethylarginine (2012)
  • Author(s): Kajimoto H, Kai H, Imaizumi T(他6人9番目)
  • Journal Title: Kidney International Volume: 81 Issue: 8 Pages: 762-768
  • DOI: 10.1038/ki.2011.476
  • Peer Reviewed
• [Journal Article] High-sensitive troponin T is associated with atrial fibrillation in a general population. (2012)
  • Author(s): Anegawa T, Kai H, Kajimoto H, YasuokaS
  • Journal Title: Int J Cardiol Volume: 156 Issue: 1 Pages: 98-100
  • DOI: 10.1016/j.ijcard.2011.12.117
  • Peer Reviewed
• [Journal Article] Selective gene expression analysis of muscular and vascular components in hearts using laser microdissection method. (2012)
  • Author(s): Ikeda A, Kai H, Kajimoto H, Yasuoka S
  • Journal Title: Int J Vasc Med Volume: Article ID 863410 Pages: 2012-2012
  • DOI: 10.1155/2012/863410
  • Peer Reviewed
• [Journal Article] Ultrasound stimulation restores impaired neovascularization-related capacities of human circulating angiogenic cells (2012)
  • Author(s): Toyama Y, Sasaki K, Tachibana K, Ueno T, Kajimoto H, Yokoyama S, Ohtsuka M, Koiwaya H, Nakayoshi T, Mitsutake Y, Chibana H, Itaya N, Imaizumi T.
  • Journal Title: Cardiovasc Res Volume: 1:95(4) Issue: 4 Pages: 448-59
  • DOI: 10.1093/cvr/cvs173
  • Peer Reviewed
• [Journal Article] Simvastatin prevents large blood pressure variability induced aggravation of cardiac hypertrophy in hypertensive rats by inhibiting RhoA/Ras-ERK pathways (2011)
  • Author(s): Takayama N, Kai H, Imaizumi T(他7人10番目)
  • Journal Title: Hypertens Res Volume: 34 Issue: 3 Pages: 341-347
  • DOI: 10.1038/hr.2010.229
  • NAID: 10031163179
  • Peer Reviewed
• [Journal Article] A Central role for CD68 (+) macrophages in hepatopulmonary syndrome: Reversal by macrophage depletion. (2011)
  • Author(s): Thenappan T, Kajimoto H
  • Journal Title: Am J Resp Crit Care Med Volume: 183 Issue: 8 Pages: 1080-1091
  • DOI: 10.1164/rccm.201008-1303oc
  • Peer Reviewed
• [Presentation] Inhibition of CaMKII/ERK-mediated eNOS phosphorylation by asymmetric dimethylarginine is novel molecular mechanism of endothelial dysfunction in chronic kidney disease mice (2012)
  • Author(s): Hidemi Kajimoto
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-16
• [Presentation] Increased Phosphatase and Tensin Homolog Plays a Crucial Role in Endothelial Dysfunction in Mice with Renal Failure. (2012)
  • Author(s): Kajimoto H, et al
  • Organizer: (American Heart Association's Scientific Sessions
  • Place of Presentation: Los Angeles, USA
• [Presentation] Inhibition of CaMKII/ERK-mediated eNOS phosphorylation by asymmetric dimethylarginine is novel molecular mechanism of endothelial dysfunction in chronic kidney disease mice. ( (2012)
  • Author(s): Kajimoto H, et al
  • Organizer: 76th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Increased Phosphatase and Tensin Homolog Plays a Crucial Role in Endothelial Dysfunction in Mice with Renal Failure. (2012)
  • Author(s): Hidemi Kajimoto
  • Organizer: American Heart Association’s Scientific Sessions
  • Place of Presentation: Los Angeles, USA
• [Presentation] Inhibition of CaMKII-and ERK-mediated eNOS phosphorylation impairs endothelial function in renal failure mice : New effect of asymmetric dimethylarginine (2011)
  • Author(s): Hidemi Kajimoto
  • Organizer: American Heart Association's Scientific Sessions
  • Place of Presentation: オーランド
  • Year and Date: 2011-11-15
• [Presentation] Inhibition of CaMKII- and ERK-mediated eNOS phosphorylation impairs endothelial function in renal failure mice: New effect of asymmetric dimethylarginine. ( (2011)
  • Author(s): Kajimoto H, et al
  • Organizer: American Heart Association's Scientific Sessions
  • Place of Presentation: Orlando, USA
• [Presentation] Increased circulating asymmetric dimethylarginine in chronic kidney disease mice induces endothelial dysfunction by inhibitingCa/Calmodulin-dependent protein kinase II-eNOS signaling. (2010)
  • Author(s): Kajimoto H, et al
  • Organizer: American Heart Association's Scientific Sessions
  • Place of Presentation: Chicago, USA
• [Presentation] Asymmetric dimethylarginine impairs endothelial function in CKD mice. (2010)
  • Author(s): Kajimoto H, et al
  • Organizer: ISN-Nexus Symposium 2010
  • Place of Presentation: Kyoto, Japan