| Project/Area Number |
22791048
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 過角化 / 遺伝子変異 / 癌 / 表皮細胞 / メラノサイト / 角化 / 遺伝性疾患 / セリンプロテアーゼ / 掌蹠 / セリンプレテアーゼ |
|---|
| Research Abstract |
Papillon-Lefevre syndrome (PLS) is characterized by palmoplantar keratosis (PPK) and early-onset periodontitis, caused by deficiency of cathepsin C (CTSC) that activates many serine proteinases. The pathogenesis of PPK in PLS has not been determined. We confirmed that CTSC activates Kallikrein 8 (KLK8) in immortal human keratinocyte line ; HaCaT cell, by stimulating with recombinant CTSC. KLK8 is one of serine proteinase, and has been reported that plays a role in shedding the corneocytes. Furthermore, histopathological finding showed that topical TPA application caused significant hyperkeratosis in the epidermis of CTSC knockout mice, compared to wild type. These findings suggest that an absence of CTSC causes a serine proteinase dysfunction, leads to hyperkeratosis in the epidermi.
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