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The gene expression profiling of the extramammary Paget's disease, identification of a surface marker and establishment of a cell line

Research Project

Project/Area Number 22791055
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionChiba University

Principal Investigator

TOGAWA Yaei  千葉大学, 大学院・医学研究院, 助教 (90361427)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords皮膚腫瘍学 / 皮膚科学 / 皮膚悪性腫瘍 / 乳房外パジェット病 / 遺伝子プロファイル
Research Abstract

We reported the efficacy for an observation technique of the Paget's cell with a fluorescence microscope in order to identify advanced lesion and small invasive lesion of extramammary Paget's disease. It was the technique based on histological staining of CEA (Paget's cell), D2-40 (lymph vessel) and Hoechst (nucleus). We also reported the first case of 68-year-old Japanese woman with metastatic HER2-positive extramammary Paget's disease that showed the validity of trastuzumab monotherapy. Trastuzumab has few side effects and is well tolerated for elderly patients. It may become a new choice of the adjubant therapy of this disease.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (5 results)

All 2012 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] Dramatic Clinical Response of Relapsed Metastatic Extramammary Paget's Disease to Trastuzumab Monotherapy2012

    • Author(s)
      S. Wakabayashi, Y. Togawa, K. Yoneyama, K. Suehiro, N. Kambe, H
    • Journal Title

      Matsue. Case reports in dermatological medicine

      Volume: Volume 2012,Article ID 401362 Pages: 1-3

    • DOI

      10.1155/2012/401362

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Melanoma in association with acquired melanocytic nevus in Japan : a review of cases in the literature2010

    • Author(s)
      Y.Togawa, Y.Nakamura, N.Kamada, N.Kambe, Y.Takahashi, H.Matsue
    • Journal Title

      Int J Dermatol.

      Volume: 49 Pages: 1362-7

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 微少浸潤を認め術後7年後に多臓器転移を来した乳房外Paget病の1例2011

    • Author(s)
      外川八英, 秋田文, 中野倫代, 末廣敬祐, 米山恭子, 塚本利郎, 鎌田憲明, 神戸直智, 松江弘之
    • Organizer
      日本皮膚科学会長崎地方会第312回例会
    • Place of Presentation
      長崎
    • Related Report
      2011 Final Research Report
  • [Presentation] 多発転移に対してtrastuzumabが著効した外陰部Paget病の1例2011

    • Author(s)
      若林正一郎, 末廣敬祐, 米山恭子, 及川真喜子, 中野倫代, 外川八英, 鎌田憲明, 松江弘之
    • Organizer
      第27回日本皮膚悪性腫瘍学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 微小浸潤像を認め術後7年後に多臓器転移をきたした乳房外Paget病の1例2010

    • Author(s)
      外川八英
    • Organizer
      宇谷厚志教授就任記念第312回日本皮膚科学会長崎地方会
    • Place of Presentation
      長崎
    • Year and Date
      2010-11-28
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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