The gene expression profiling of the extramammary Paget's disease, identification of a surface marker and establishment of a cell line

• Project/Area Number: 22791055
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Chiba University
• Principal Investigator: TOGAWA Yaei 千葉大学, 大学院・医学研究院, 助教 (90361427)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 皮膚腫瘍学 / 皮膚科学 / 皮膚悪性腫瘍 / 乳房外パジェット病 / 遺伝子プロファイル

Research Abstract

We reported the efficacy for an observation technique of the Paget's cell with a fluorescence microscope in order to identify advanced lesion and small invasive lesion of extramammary Paget's disease. It was the technique based on histological staining of CEA (Paget's cell), D2-40 (lymph vessel) and Hoechst (nucleus). We also reported the first case of 68-year-old Japanese woman with metastatic HER2-positive extramammary Paget's disease that showed the validity of trastuzumab monotherapy. Trastuzumab has few side effects and is well tolerated for elderly patients. It may become a new choice of the adjubant therapy of this disease.

Research Products

• [Journal Article] Dramatic Clinical Response of Relapsed Metastatic Extramammary Paget's Disease to Trastuzumab Monotherapy (2012)
  • Author(s): S. Wakabayashi, Y. Togawa, K. Yoneyama, K. Suehiro, N. Kambe, H
  • Journal Title: Matsue. Case reports in dermatological medicine Volume: Volume 2012,Article ID 401362 Pages: 1-3
  • DOI: 10.1155/2012/401362
  • Peer Reviewed
• [Journal Article] Melanoma in association with acquired melanocytic nevus in Japan : a review of cases in the literature (2010)
  • Author(s): Y.Togawa, Y.Nakamura, N.Kamada, N.Kambe, Y.Takahashi, H.Matsue
  • Journal Title: Int J Dermatol. Volume: 49 Pages: 1362-7
  • Peer Reviewed
• [Presentation] 微少浸潤を認め術後7年後に多臓器転移を来した乳房外Paget病の1例 (2011)
  • Author(s): 外川八英, 秋田文, 中野倫代, 末廣敬祐, 米山恭子, 塚本利郎, 鎌田憲明, 神戸直智, 松江弘之
  • Organizer: 日本皮膚科学会長崎地方会第312回例会
  • Place of Presentation: 長崎
• [Presentation] 多発転移に対してtrastuzumabが著効した外陰部Paget病の1例 (2011)
  • Author(s): 若林正一郎, 末廣敬祐, 米山恭子, 及川真喜子, 中野倫代, 外川八英, 鎌田憲明, 松江弘之
  • Organizer: 第27回日本皮膚悪性腫瘍学会学術大会
  • Place of Presentation: 東京
• [Presentation] 微小浸潤像を認め術後7年後に多臓器転移をきたした乳房外Paget病の1例 (2010)
  • Author(s): 外川八英
  • Organizer: 宇谷厚志教授就任記念第312回日本皮膚科学会長崎地方会
  • Place of Presentation: 長崎
  • Year and Date: 2010-11-28