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The development of tailor-made molecular target therapy by circulating tumor cells and microRNAs in melanoma patients

Research Project

Project/Area Number 22791065
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionShinshu University

Principal Investigator

GOTO Yasufumi  信州大学, 医学部, 非常勤講師 (60467181)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords皮膚腫瘍学 / 悪性黒色腫 / microRNA / マイクロビーズ / バイオマーカー / BRAF / KIT / mir214 / 抗癌剤耐性
Research Abstract

We established the methods of isolating circulating tumor cells from melanoma patients by using the magnetic beads and melanoma specific antibodies. CTC genotyping may be useful as a biomarker of molecular-targeted therapy by using BRAF inhibitor for melanoma patients.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (22 results)

All 2012 2011 2010 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (9 results) Remarks (2 results)

  • [Journal Article] Assessment of BRAF and KIT mutations in Japanese melanoma patients2012

    • Author(s)
      Ashida A, Uhara H, Kiniwa Y, Oguchi M, Murata H, Goto Y, Uchiyama A, Ogawa E, Hayashi K, Koga H, Okuyama R
    • Journal Title

      J Dermatol Sci

      Volume: 5 Pages: 240-242

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutation analysis of BRAF and KIT in circulating melanoma cells at the single cell level2012

    • Author(s)
      Sakaizawa K, Goto Y, Kiniwa Y, et al
    • Journal Title

      Br J Cancer

      Volume: 106 Issue: 5 Pages: 939-946

    • DOI

      10.1038/bjc.2012.12

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid progression of hidradenitis suppurativa in the lower leg of a patient with psoriasis vulgaris2012

    • Author(s)
      Tanaka A, Goto Y, Iwade M, Uhara H, Okuyama R.
    • Journal Title

      Acta Derm Venereol

      Volume: 92(1) Pages: 105-6

    • NAID

      120007100104

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid progression of hidradenitis suppurativa in the lower leg of a patient with psoriasis vulgaris2012

    • Author(s)
      Tanaka A, Goto Y, Iwade M, Uhara H, Okuyama R
    • Journal Title

      Acta Derm Venereol

      Volume: 92 Issue: 1 Pages: 105-6

    • DOI

      10.2340/00015555-1182

    • NAID

      120007100104

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation analysis of BRAF and KIT in circulating melanoma cells at the single cell level. Assessment of BRAF and KIT mutations in Japanese melanoma patients2012

    • Author(s)
      Sakaizawa K, Goto Y, Kiniwa Y, Uchiyama A, Harada K, Shimada S, Saida T, Ferrone S, Takata M, Uhara H, Okuyama R
    • Journal Title

      Br J Cancer

      Volume: 106 Pages: 939-46

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polyclonality of BRAF mutations in primary melanoma and the selection of mutant alleles during progression2011

    • Author(s)
      Lin J, Goto Y, Murata H, Sakaizawa K, Uchiyama A, Saida T, Takata M
    • Journal Title

      Br J Cancer

      Volume: 11 Pages: 464-468

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] THAP5 is a DNA-binding transcriptional repressor that is regulated in melanoma cells during DNA damage-induced cell death2011

    • Author(s)
      Balakrishnan MP, Cilenti L, Ambivero C, Goto Y, Takata M, Turkson J, Li XS, Zervos AS
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 404(1) Pages: 195-200

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leg Ulcers Associated with Positive Lupus Anticoagulant in Two Cases of Klinefelter's Syndrome2011

    • Author(s)
      Goto Y, Uhara H, Murata H, Koga H, Kosho T, Yamazaki M, Takata M, Okuyama R.
    • Journal Title

      Acta Derm Venereol

      Volume: 91 Pages: 90-91

    • NAID

      120007100108

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] THAP5 is a DNA-binding transcriptional repressor that is regulated in melanoma cells during DNA damage-induced cell death2011

    • Author(s)
      Balakrishnan MP, Cilenti L, Ambivero C, Goto Y, Takata M, Turkson J, Li XS, Zervos AS
    • Journal Title

      Biochem Biophys Res Commu

      Volume: 404 Pages: 195-200

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Leg Ulcers Associated with Positive Lupus Anticoagulant in Two Cases of Klinefelter' s Syndrome2010

    • Author(s)
      Goto Y, Uhara H, Murata H, Koga H, Kosho T, Yamazaki M, Takata M, Okuyama R
    • Journal Title

      Acta Derm Venereol

      Pages: 90-91

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of BRAF and KIT mutations in Japanese melanoma patients

    • Author(s)
      Ashida A, Uhara H, Kiniwa Y, Oguchi M, Murata H, Goto Y, Uchiyama A, Ogawa E, Hayashi K, Koga H, Okuyama R
    • Journal Title

      J Dermatol Sci

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] FABP7 gene expression during malignant melanoma progression : Utility as a prognostic molecular marker2010

    • Author(s)
      後藤康文
    • Organizer
      第35回日本研究皮膚科学会総会
    • Place of Presentation
      和歌山
    • Year and Date
      2010-12-03
    • Related Report
      2011 Final Research Report
  • [Presentation] FABP7 gene expression in association with melanoma progression : Utility as a prognostic marker2010

    • Author(s)
      後藤康文
    • Organizer
      第35回日本研究皮膚科学会総会
    • Place of Presentation
      和歌山市
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Activation of Toll-Like Receptor 4 on human melanoma cells induced cell proliferation and migration2010

    • Author(s)
      後藤康文
    • Organizer
      Melanoma Congres2010
    • Place of Presentation
      シドニー
    • Year and Date
      2010-11-04
    • Related Report
      2011 Final Research Report
  • [Presentation] The activation of Toll-Like Receptor 4 on human melanoma cells induced cell proliferation and migration2010

    • Author(s)
      後藤康文
    • Organizer
      Melanoma Congres2010
    • Place of Presentation
      シドニー
    • Year and Date
      2010-11-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血液循環メラノーマ細胞におけるBRAFとKIT遺伝子の解析2010

    • Author(s)
      後藤康文
    • Organizer
      メラノーマ班会議
    • Place of Presentation
      東京
    • Year and Date
      2010-07-31
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 爪甲メラノーマへの対応2010

    • Author(s)
      後藤康文
    • Organizer
      109回日本皮膚科学会総会・教育講演
    • Place of Presentation
      大阪
    • Year and Date
      2010-04-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 抗リン脂質抗体症候群(APS)を合併したKlinefelter症候群に生じた下腿潰瘍の2例2010

    • Author(s)
      後藤康文
    • Organizer
      109回日本皮膚科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-04-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 爪甲メラノーマへの対応2010

    • Author(s)
      後藤康文
    • Organizer
      109回日本皮膚科学会総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-04-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗リン脂質抗体症候群(APS)を合併したKlinefelter症候群に生じた下腿潰瘍の2例2010

    • Author(s)
      後藤康文
    • Organizer
      109回日本皮膚科学会総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-04-16
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.shinshu-u.ac.jp/faculty/medicine/chair/i-hifu/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.shinshu-u.ac.jp/faculty/medicine/chair/i-hifu/index.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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