The investigation for various factors which regulates cutaneous inflammation

• Project/Area Number: 22791072
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Kobe University
• Principal Investigator: FUKUNAGA Atsushi 神戸大学, 医学研究科, 助教 (10467649)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 紫外線 / 接触皮膚炎 / チオレドキシン / NKT細胞 / 制御性T細胞 / 皮膚炎症 / ランゲルハンス細 / 紫外線免疫 / ランゲルハンス細胞

Research Abstract

The contact hypersensitivity response was suppressed by narrowband UVB irradiation. Epidermal langerhans cells were indispensable for this suppression. In addition, the application of human recombinant thioredoxin inhibited contact hypersensitivity response and a primary irritant dermatitis.

Research Products

• [Journal Article] An unusual case of bathing suit ichthyosis with summer exacerbation (2012)
  • Author(s): Yamamoto M, Sakaguchi Y. Itoh M, Nakagawa N, Fukunaga A, Hitomi K, Yamanishi K
  • Journal Title: Br J Dermatol Volume: 166 Issue: 3 Pages: 672-674
  • DOI: 10.1111/j.1365-2133.2011.10594.x
  • Peer Reviewed
• [Journal Article] Rapid Desensitization with Autologous Sweat in Cholinergic Urticaria (2011)
  • Author(s): Kozaru T, Fukunaga A, Taguchi K, Ogura K, Nagano T, Oka M, Horikawa T, Nishigori C.
  • Journal Title: Allergol Int Volume: 60 Pages: 277-81
  • NAID: 130004723038
  • Peer Reviewed
• [Journal Article] Rapid Desensitization with Autologous Sweat in Cholinergic Urticaria (2011)
  • Author(s): Kozaru T, Fukunaga A, Tagchi K, Ogura K, Nagano T, Oka M, Horikawa T, Nishigori C
  • Journal Title: Allergol Int Volume: 60 Pages: 277-281
  • NAID: 130004723038
  • Peer Reviewed
• [Journal Article] Limited influence of aspirin intake on mast cell activation in patients with food-dependent ecercise-induced anaphylaxis : comparison using skin prick and histamine release tests (2011)
  • Author(s): Fukunaga A, Shimizu H, Tanaka M, Kikuzawa A, Tsujimoto M, Sekimukai A, Yamashita J, Horikawa T, Nishigori C
  • Journal Title: Ada Derm Venereol Volume: (Epub ahead of print) Issue: 5 Pages: 480-483
  • DOI: 10.2340/00015555-1210
  • Peer Reviewed
• [Journal Article] Drug fever due to S-carboxymethyl-L-cysteine : The demonstrati on of a causative agent with patch tests (2011)
  • Author(s): Hatakeyama M, Fukunaga A, Shimizu H, Oka M, Horikawa T, Nishigori C
  • Journal Title: J Dermatol Volume: (Epub ahead of print) Issue: 6 Pages: 555-556
  • DOI: 10.1111/j.1346-8138.2011.01325.x
  • Peer Reviewed
• [Journal Article] Successful treatment with adapalene of cetuximab-induced acneiform eruptions (2011)
  • Author(s): Taguchi K, Fukunaga A, Okuno T, Nishigori C
  • Journal Title: J Dermatol Volume: (Epub ahead of print) Issue: 9 Pages: 792-794
  • DOI: 10.1111/j.1346-8138.2011.01424.x
  • Peer Reviewed
• [Journal Article] Desensitization therapy with autologous sweat in cholinergicurticaria (2011)
  • Author(s): Fukunaga A
  • Journal Title: J Enviromen Dermatol Cutan Allergol Volume: 5 Pages: 380-386
• [Journal Article] Langerhans Cells Serve as Immunoregulatory Cells by Activating NKT Cells (2010)
  • Author(s): Fukunaga A, Khaskhely NM, Ma Y, Sreevidya CS, Taguchi K, Nishigori C, Ullrich SE.
  • Journal Title: Immunol Volume: 185 Pages: 4633-40
  • Peer Reviewed
• [Journal Article] Agents that reverse UV-induced immune suppression affect DNA repair (2010)
  • Author(s): Sreevidya CS, Fukunaga A, Khaskhely NM, Masaki T, Ono R, Nishigori C, Ullrich SE.
  • Journal Title: J Invest Dermatol Volume: 130 Pages: 1428-37
  • Peer Reviewed
• [Journal Article] Non-occupational allergic contact dermatitis from 2-N-octyl-4-isothiazolin-3-one in a Japanese mattress gel-sheet used for cooling (2010)
  • Author(s): Fukunaga A, Nishiyama S, Shimizu H, Nagai H, Horikawa T, Mori A, Inoue N, Sasaki K, Nishigori C.
  • Journal Title: Contact Dermatitis Volume: 62 Pages: 317-8
  • Peer Reviewed
• [Journal Article] Aspirin-intolerant chronic urticaria exacerbated by cutaneous application of a ketoprofen poultice (2010)
  • Author(s): Fukunaga A, Hatakeyama M, Taguchi K, Shimizu H, Horikawa T, Nishigori C.
  • Journal Title: Acta Derm Venereol Volume: 90 Pages: 413-5
  • Peer Reviewed
• [Journal Article] Agents that reverse UV induced immune suppression affect DNA repair (2010)
  • Author(s): Sreevidya CS, Fukunaga A, Khaskhely NM, Masaki T, Ono R, Nishigori C, Ullrich SE.
  • Journal Title: J Invest Dermatol. Volume: 130 Pages: 1428-1437
  • Peer Reviewed
• [Journal Article] Non-occupational allergic contact dermatitis from 2-N-octyl-4-isothiazolin-3-one in a Japanese mattress gel-sheet used for cooling. (2010)
  • Author(s): Fukunaga A, Nishiyama S, Shimizu H, Nagai H, Horikawa T, Mori A, Inoue N, Sasaki K, Nishigori C.
  • Journal Title: Contact Dermatitis. Volume: 62 Pages: 317-318
  • Peer Reviewed
• [Journal Article] Aspirin-intolerant chronic urticaria exacerbated by cutaneous application of a ketoprofen poultice. (2010)
  • Author(s): Fukunaga A, Hatakeyama M, Taguchi K, Shimizu H, Horikawa T, Nishigori C.
  • Journal Title: Acta Derm Venereol. Volume: 90 Pages: 413-415
  • Peer Reviewed
• [Journal Article] Axillary accessory breast associated with galactorrhea in an adolescent girl. (2010)
  • Author(s): Kyo A, Oka M, Sasaki Y, Fukunaga A, Nagano T, Funasaka Y, Nishigori C.
  • Journal Title: Dermato-Endocrinology Volume: 2 Pages: 39-40
  • Peer Reviewed
• [Journal Article] Langerhans Cells Serve as Immunoregulatory Cells by Activating NKT Cells. (2010)
  • Author(s): Fukunaga A, Khaskhely NM, Ma Y, Sreevidya CS, Taguchi K, Nishigori C, Ullrich SE.
  • Journal Title: J Immunol. Volume: 185 Pages: 4633-4640
  • Peer Reviewed
• [Journal Article] Ischemic fasciitis with MRI findings (2010)
  • Author(s): Gokita M, Shimizu H, Sakaguchi M, Fukunaga A, Kunisada M, Oka M, Fujii M, Nishigori C.Ischemic fasciitis, MRI findings.
  • Journal Title: Eur J Dermatol. Volume: 20 Pages: 847-848
  • Peer Reviewed
• [Presentation] アスピリンによる食物依存性運動誘発アナフィラキシー症状の誘発における肥満細胞の関与の検討 (2011)
  • Author(s): 指宿千恵子、菊澤亜夕子、田中真実、清水秀樹、福永淳、錦織千佳子(以上神戸大学)、堀川達弥(西神戸医療センター)
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-10
• [Presentation] 夏季に増悪するbathing suit ichthyosis (2011)
  • Author(s): 山西清文、山本雅章、坂口祥子(以上兵庫医大)、福永淳
  • Organizer: 第26回角化症研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-07-30
• [Presentation] 神戸大学皮膚科における日光蕁麻疹症例の臨床的検討 (2011)
  • Author(s): 田島翔子、福永淳、錦織千佳子
  • Organizer: 第33回日本光医学・光生物学会
  • Place of Presentation: 大阪
  • Year and Date: 2011-07-22
• [Presentation] ニューキノロン系抗生剤による即時型アレルギー2例の交差反応についての検討 (2011)
  • Author(s): 神保晴紀、古松茜、福永淳、清水秀樹、錦織千佳子、山下純史、皿山泰子*、原田晋**(*:神戸労災病院皮膚科、**:はらだ皮膚科クリニック)
  • Organizer: 第41回日本皮膚アレルギー・接触皮膚炎学会総会・学術大会
  • Place of Presentation: 山梨
  • Year and Date: 2011-07-16
• [Presentation] UVA急速減感作療法が著効した日光蕁麻疹の2例-作用機序の検討を含めて (2011)
  • Author(s): 岸上景子、舛岡恵律子、神保晴紀、西岡美南、内村友佳、福永淳、錦織千佳子
  • Organizer: 第41回日本皮膚アレルギー・接触皮膚炎学会総会・学術大会
  • Place of Presentation: 山梨
  • Year and Date: 2011-07-16
• [Presentation] 痒疹様結節と口腔カンジダ症を契機に診断に至った後天性免疫不全症候群の1例 (2011)
  • Author(s): 鷲尾健、田中真実、福永淳、尾藤利憲、岡昌宏、錦織千佳子
  • Organizer: 第27回日本臨床皮膚科医会総会・臨床学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2011-06-11
• [Presentation] Both the elicitation phase of contact hypersensitivity response and irritant dermatitis are suppressed by administration of thioredoxin. (2010)
  • Author(s): Atsushi Fukunaga, Tatsuya Horikawa, Kanako Ogura, Kumiko Taguchi, Xijun Yu, Yoko Funasaka, Masafumi Takeda, Hajime Nakamura, Junji Yodoi, Chikako Nishigori
  • Organizer: 2010 SID Annual Meeting
  • Place of Presentation: Atlanta Hilton (USA)
• [Presentation] Recombinant Human Thioredoxin Attenuates UVB-Induced Oxidative Damage in Murine Skin by Reducing ROS and Phosphorylation of Stress-Activated Protein Kinase. (2010)
  • Author(s): Ryusuke Ono, Siphora Dien, Taro Masaki, Xijun Yu, Atsushi Fukunaga, Junji Yodoi, Chikako Nishigori
  • Organizer: American Society for Photobiology 2010
  • Place of Presentation: Brown University (USA)
• [Presentation] Best timing of topical application of DNA repair enzyme to obtain both reduction of cyclobutane pyrimidine dimers and sustaining immune suppression sgyrt Narrow Band UVB exposure. (2010)
  • Author(s): Siphora Dien, Kumiko Taguchi, Atsushi Fukunaga, Chikako Nishigori
  • Organizer: American Society for Photobiology 2010
  • Place of Presentation: Brown University (USA)
• [Presentation] Recombinant Human Thioredoxin Attenuates UVB-Induced Oxidative Damage in Murine Skin by Reducing ROS and Inhibiting Phosphorylation of SAPK. (2010)
  • Author(s): Ryusuke Ono, Siphora Dien, Taro Masaki, Xijun Yu, Atsushi Fukunaga, Junji Yodoi, Chikako Nishigori
  • Organizer: The 35th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 和歌山県民文化会館(和歌山県)
• [Presentation] Rho kinase pathway regulates contact hypersensitivity response by regulating DC migration through SHPS-1. (2010)
  • Author(s): Kanako Ogura, Atsushi Fukunaga, Shuntaro Oniki, Hiroshi Nagai, Hideki Okazawa, Takashi Matozaki, Chikako Nishigori, Tatsuya Horikawa
  • Organizer: The 35th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 和歌山県民文化会館(和歌山県)
• [Presentation] B The role of cutaneous dendritic cells in narrowband UVB-induced immunosuppression. (2010)
  • Author(s): Kumiko Taguchi, Atsushi Fukunaga, Kanako Ogura, Chikako Nishigori
  • Organizer: The 35th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 和歌山県民文化会館(和歌山県)
• [Presentation] コリン性奪麻疹の自己汗による減感作療法 (2010)
  • Author(s): 福永淳
  • Organizer: 第40回日本皮膚アレルギー・接触皮膚炎学会総会学術大会(シンポジウム)
  • Place of Presentation: 広島国際会議場(広島県)(招待講演)
• [Presentation] The role of cutaneous dendritic cells in narrowband UVB-induced immunosuppression
  • Author(s): Kumiko Taguchi, Atsushi Fukunaga, Kanako Ogura, Chikako Nishigori.
  • Organizer: The 35th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] Both the elicitation phase of contact hypersensitivity response and irritant dermatitis are suppressed by administration of thioredoxin
  • Author(s): Atsushi Fukunaga, Tatsuya Horikawa, Kanako Ogura, Kumiko Taguchi, Xijun Yu, Yoko Funasaka, Masafumi Takeda, Hajime Nakamura, Junji Yodoi, Chikako Nishigori
  • Organizer: 2010 SID Annual Meeting
• [Presentation] Rho kinase pathway regulates contact hypersensitivity response by regulating DC migration through SHPS-1
  • Author(s): Kanako Ogura, Atsushi Fukunaga, Shuntaro Oniki, Hiroshi Nagai, Hideki Okazawa, Takashi Matozaki, Chikako Nishigori, Tatsuya Horikawa
  • Organizer: The 35th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Book] Solar urticaria.Urticaria and Angioedema (2010)
  • Author(s): Horikawa T, Fuuknaga A, Nishigori C
  • Total Pages: 158
  • Publisher: Springer