An effect of Th2 environment on kallikrein expression in keratinocytes and skin barrier

• Project/Area Number: 22791074
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Okayama University
• Principal Investigator: MORIZANE Shin 岡山大学, 岡山大学病院, 助教 (80423333)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: アトピー性皮膚炎 / カリクレイン / Th2サイトカイン

Research Abstract

We found that Th2 cytokines, IL-4 and IL-13, increase kallikrein 7 expression and function in keratinocytes. Further, KLK7 protein level in the sera of atopic dermatitis patients significantly correlated with IL-4 amounts in the sera. Our finding describes a link between the Th2 environment and epidermal barrier dysfunction in atopic dermatitis.

Research Products

• [Journal Article] 角化細胞産生カリクレイン発現および皮膚バリア (2011)
  • Author(s): 森実真
  • Journal Title: 皮膚の科学 Volume: 10巻 Pages: 29-33
• [Presentation] アトピー性皮膚炎の表皮角化細胞における組織カリクレイン7の発現 (2011)
  • Author(s): 森実真
  • Organizer: 日本皮膚科学会愛媛地方会,第54回学術大会
  • Place of Presentation: 松山全日空ホテル、松山
  • Year and Date: 2011-09-24
• [Presentation] アトピー性皮膚炎の表皮角化細胞における組織カリクレイン7の発現 (2011)
  • Author(s): 森実真
  • Organizer: 日本皮膚科学会愛媛地方会第54回学術大会
  • Place of Presentation: 松山全日空ホテル
  • Year and Date: 2011-09-24
• [Presentation] 角化細胞産生カリクレイン発現および皮膚バリア (2011)
  • Author(s): 森実真
  • Organizer: アトピー性皮膚炎治療研究会第16回シンポジウム
  • Place of Presentation: 北九州国際会議場、小倉
  • Year and Date: 2011-02-05
• [Presentation] アトピー性皮膚炎における角化細胞産生カリクレイン7の発現制御機構 (2010)
  • Author(s): 森実真
  • Organizer: 第40回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 広島国際会議場、広島
• [Presentation] Tissue kallikren 7 expression and the protease activity in keratinocytes are enhanced by Th2 cytokines in atopic dermatitis (2010)
  • Author(s): Shin Morizane
  • Organizer: 日本研究皮膚科学会第35回年次学術大会・総会
  • Place of Presentation: 和歌山県民文化会館、和歌山
• [Presentation] Th2 cytokines enhance tissue kallikrein 7 expression and the serine protease activity of keratinocytes in atopic dermatitis (2010)
  • Author(s): Shin Morizane
  • Organizer: The 40th annual meeting of the European Society for Dermatological Research
  • Place of Presentation: Helsinki, Finland
• [Presentation] Th2 cytokines enhance tissue kallikreins and serine protease activity of keratinocytes in atopic dermatitis (2010)
  • Author(s): Shin Morizane
  • Organizer: The 70th annual meeting of Society for Investigative Dermatology
  • Place of Presentation: Atlanta, USA
• [Presentation] Th2 cytokines enhance tissue kallikreins and serine protease activity of keratinocytes in atopic dermatitis (2010)
  • Author(s): Shin Morizane
  • Organizer: The 70th annual meeting of Society for Investigative Dermatology
  • Place of Presentation: Atianta, U.S.A.
• [Presentation] Tissue kallikrein 7 expression and the protease activity in keratinocytes are enhanced by Th2 cytokines in atopic dermatitis (2010)
  • Author(s): Shin Morizane
  • Organizer: 日本研究皮膚科学会 第35回年次学術大会・総会
  • Place of Presentation: 和歌山県民文化会館、和歌山