Structural determinant of Humanβ-defensin-3 to stimulate cytokine/chemokine secretion
| Project/Area Number |
22791075
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | ヒトβデフェンシン-3 / αヘリカル / アルギニン / IL-6 / IL-8 / デフェンシン / αヘリクス / サイトカイン |
|---|
| Research Abstract |
Humanβ-defensin-3(HBD-3) possesses an ability to stimulate proinflammatory cytokine/chemokine secretion, which links innate and adaptive immunity, as well as antimicrobial activity. Although we hypothesized thatα-helics in N-terminal is a structural determinant for this function and examined the effect on normal human epidermal keratinocytes to secrete IL-6 and-8, the secretion of IL-6 and-8 was associated with two Arg residues in C-terminal unique motif of HBD-3 not withα-helics.
|
Report
(3 results)
Research Products
(6 results)
