Approaches to the pathogenesis of psoriasis, an intractable human skin disorder

• Project/Area Number: 22791078
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: The University of Tokushima
• Principal Investigator: MOURI Yasuhiro 徳島大学, 疾患酵素学研究センター, 助教 (80464353)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 乾癬 / サイトカイン / 皮膚 / コルネオデスモシン

Research Abstract

Psoriasis is an intractable skin disorder whose pathogenesis is unknown. It is not clear whether autoimmunity is involved in the pathogenesis of psoriasis. Because corneodesmosin (CDSN)-deficient mice show the skin phenotypes resembling human psoriasis, we administered neutralizing antibody against IL-22 into the recipient mice grafted with CDSN-deficient skin. We found no obvious changes in the skin phenotypes by the injection of anti-IL-22 neutralizing antibody. We also need to see, however, whether the concomitant administration of neutralizing antibody against IL-23, a Th17 inflammatory cytokine, would show the same results in order to know to determine further the autoimmune features of psoriasis in the future.

Research Products

• [Journal Article] Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma (2011)
  • Author(s): Mouri Y
  • Journal Title: Journal of Immunology Volume: 186 Issue: 9 Pages: 5047-5057
  • DOI: 10.4049/jimmunol.1003533
  • Peer Reviewed
• [Journal Article] Biphasic Aire ｅxpression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation. (2010)
  • Author(s): Nishikawa Y, Hirota F, Yano M, Kitajima H, Miyazaki J, Kawamoto H, Mouri Y, Matsumoto M
  • Journal Title: J Exp Med. Volume: 207 Issue: 5 Pages: 963-971
  • DOI: 10.1084/jem.20092144
  • Peer Reviewed
• [Journal Article] Biphasic Aire expression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation. (2010)
  • Author(s): Nishikawa, Y., et al.
  • Journal Title: J.Exp.Med. Volume: Vol.207 Pages: 963-971
  • Peer Reviewed
• [Presentation] Differential requirement of Aire in two transgenic models for the negative selection of autoreactive thymocytes against self-antigens (2012)
  • Author(s): Mouri, Y., Nishikawa, Y., Nishijima, H, and Matsumoto, M
  • Organizer: 第41回日本免疫学会総会
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2012-12-06
• [Presentation] モデル自己抗原遺伝子導入トランエウジェニックマウスを用いたAire依存的負の選択機構の解析 (2012)
  • Author(s): 毛利安宏、西川裕美子、西嶋 仁、松本 満
  • Organizer: 第22回 Kyoto T Cell Conference
  • Place of Presentation: 和順会館(京都市)
  • Year and Date: 2012-07-06
• [Presentation] Temporal fate-mapping reveals essential roles of Aire in the maturation program of mTECs (2012)
  • Author(s): Matsumoto, M., Nishikawa, Y., Mouri, Y., Hirota F., and Nishijima, H
  • Organizer: ThymUS 2012
  • Place of Presentation: Trump International Beach Resort, Sunny Isles Beach, USA
• [Presentation] モデル自己抗原遺伝子導入トランエウジェニックマウスを用いたAire依存的負の選択機構の解析 (2012)
  • Author(s): 毛利安宏
  • Organizer: 第22回 Kyoto T Cell Conference
  • Place of Presentation: 和順会館（京都府）
• [Presentation] Temporal fate-mapping reveals essential roles of Aire in the maturation program of mTECs (2012)
  • Author(s): Matsumoto M.
  • Organizer: ThymUS 2012
  • Place of Presentation: Trump International Beach Resort（USA）
• [Presentation] Differential requirement of Aire in two transgenic models for the negative selection of autoreactive thymocytes against self-antigens (2012)
  • Author(s): Mouri Y.
  • Organizer: 第41回日本免疫学会総会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] AIRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化 (2011)
  • Author(s): 西嶋 仁、毛利安宏、西川裕美子、松本 満
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 幕張メッセ(千葉市)
  • Year and Date: 2011-11-27
• [Presentation] Negative selectionにおけるAire発現細胞由来自己抗原の役割 (2011)
  • Author(s): 毛利安宏、西川裕美子、西嶋 仁、松本 満
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 幕張メッセ(千葉市)
  • Year and Date: 2011-11-27
• [Presentation] Negative selectionにおけるAire発現細胞由来自己抗原の役割 (2011)
  • Author(s): 毛利安宏, 他
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 幕張メッセ、千葉県
  • Year and Date: 2011-11-27
• [Presentation] Role of self-antigen expressed by Aire-expressing cells in the negative selection process (2011)
  • Author(s): Matsumoto, M., et al
  • Organizer: 5th International Conference on Autoimmunity Mechanisms and Novel Treatments
  • Place of Presentation: Crete, Greece
  • Year and Date: 2011-09-24
• [Presentation] Aire-dependent organization of thymic micrcoenvironment for the establishment of self tolerance (2011)
  • Author(s): Matsumoto, M., et al
  • Organizer: EUThyme-Rolduc Meeting
  • Place of Presentation: Leeuwenhorst, The Netherlands
  • Year and Date: 2011-05-22
• [Presentation] Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma (2011)
  • Author(s): Mouri, Y., et al
  • Organizer: 13^<th> International TNF Conference, TNF 2011
  • Place of Presentation: Awaji, Hyogo, Japan
  • Year and Date: 2011-05-16
• [Presentation] Role of Aire in the organization of thymic microenvironment (2011)
  • Author(s): Matsumoto, M., et al.
  • Organizer: Controversies in Rheumatology and Autoimmunity (CORA 2011)
  • Place of Presentation: Firenze Fiera, Florence, Italy
  • Year and Date: 2011-03-10
• [Presentation] Role of self-antigen expressed by Aire-expressing cells in the negative selection process (2011)
  • Author(s): Matsumoto, M., Mouri, Y., Nishikawa, Y., and Nishijima, H
  • Organizer: 5th International Conference on Autoimmunity: Mechanisms and Novel Treatments
  • Place of Presentation: Knossos Royal Village Conference Center, Hersonissos, Crete, Greece
• [Presentation] Aire-dependent organization of thymic microenvironment for the establishment of self tolerance (2011)
  • Author(s): Matsumoto, M., Nishikawa, Y., Mouri, Y., and Nishijima, H
  • Organizer: EUThyme-Rolduc Meeting
  • Place of Presentation: NH Conference Center, Leeuwenhorst, The Netherlands
• [Presentation] Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma (2011)
  • Author(s): Mouri, Y., Yano, M.,Shinzawa, M., Shimo, Y., Nishikawa, Y., Tamada, K., Chen, L., Penninger, J.M., Inoue, J., Akiyama, T., and Matsumoto, M
  • Organizer: 13thInternational TNF Conference, TNF 2011
  • Place of Presentation: Awaji Yumebutai International Conference Center(淡路市)
• [Presentation] Aire-dependent organization of thymic microenvironment for the establishment of self-tolerance (2011)
  • Author(s): Nishikawa, Y., Mouri, Y., Nishijima, H., and Matsumoto, M
  • Organizer: ESF-JSPS Frontier Science Conference Series for Young Researchers 「Cutting Edge Immunology and its Clinical Application」
  • Place of Presentation: Apollo Hotel de Beyaerd, Hulshort, The Netherlands
• [Presentation] Roles of thymic epithelial cells for the establishment of self-tolerance (2010)
  • Author(s): Matsumoto, M., et al.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe Portopia Hotel, Kobe, Japan
  • Year and Date: 2010-08-26
• [Presentation] Aire in thymic epithelial cells in the medulla controls developmental process of thymocytes (2010)
  • Author(s): Mouri, Y., Nishikawa, Y., and Matsumoto, M
  • Organizer: 4thInternational Congress of Immunology
  • Place of Presentation: Kobe Portopia Hotel(神戸市)
  • Year and Date: 2010-08-24
• [Presentation] Aire in thymic epithelial cells in the medulla controls developmental process of thymocytes (2010)
  • Author(s): Mouri, Y., et al.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe Portopia Hotel, Kobe, Japan
  • Year and Date: 2010-08-24
• [Presentation] Biphasic Aire expression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation (2010)
  • Author(s): Nishikawa, Y., Mouri, Y., and Matsumoto, M
  • Organizer: 14thInternational Congress of Immunology
  • Place of Presentation: Kobe Portopia Hotel(神戸市)
  • Year and Date: 2010-08-23
• [Presentation] Biphasic Aire expression in early embryos and in medullary thymic epithelial cells prior to end-stage terminal differentiation (2010)
  • Author(s): Nishikawa, Y., et al
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe Portopia Hotel, Kobe, Japan
  • Year and Date: 2010-08-23
• [Presentation] AIRE and autoimmune disease (2010)
  • Author(s): Matsumoto, M., Nishikawa, Y., Hirota, F. and Mouri, Y
  • Organizer: The 19thInternational Rheumatology Symposium
  • Place of Presentation: Kobe Portopia Hotel(神戸市)
  • Year and Date: 2010-04-23
• [Presentation] AIRE and autoimmune disease (2010)
  • Author(s): Matsumoto, M., et al
  • Organizer: The 19^<th> International Rheumatology Symposium
  • Place of Presentation: Kobe Portopia Hotel, Kobe, Japan
  • Year and Date: 2010-04-23
• [Remarks]
  • URL: http://mms1.ier.tokushima-u.ac.jp/article/0017775.html