| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
Psoriasis is an intractable skin disorder whose pathogenesis is unknown. It is not clear whether autoimmunity is involved in the pathogenesis of psoriasis. Because corneodesmosin (CDSN)-deficient mice show the skin phenotypes resembling human psoriasis, we administered neutralizing antibody against IL-22 into the recipient mice grafted with CDSN-deficient skin. We found no obvious changes in the skin phenotypes by the injection of anti-IL-22 neutralizing antibody. We also need to see, however, whether the concomitant administration of neutralizing antibody against IL-23, a Th17 inflammatory cytokine, would show the same results in order to know to determine further the autoimmune features of psoriasis in the future.
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