Development of immunotherapy targeting melanoma stem cells.
| Project/Area Number |
22791087
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 皮膚腫瘍学 / 癌幹細胞 / 腫瘍免疫 / 腫癌免疫 |
|---|
| Research Abstract |
We have previously isolated melanoma-stem cell like population in Side Population(SP). In this study, we analyzed genes expressed by hypoxia in those SP cells. We also found antibodies against novel cancer testis antigen specifically expressed by melanoma SP cells in melanoma patients. In addition, we have identified HLA-A 2402-restricted peptide in this cancer testis antigen. These results will be useful for development novel immunotherapy targeting cancer stem cells in melanoma patients.
|
Report
(3 results)
Research Products
(4 results)
