| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We have previously isolated melanoma-stem cell like population in Side Population(SP). In this study, we analyzed genes expressed by hypoxia in those SP cells. We also found antibodies against novel cancer testis antigen specifically expressed by melanoma SP cells in melanoma patients. In addition, we have identified HLA-A 2402-restricted peptide in this cancer testis antigen. These results will be useful for development novel immunotherapy targeting cancer stem cells in melanoma patients.
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