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Development of immunotherapy targeting melanoma stem cells.

Research Project

Project/Area Number 22791087
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionKeio University

Principal Investigator

MATSUSHITA Maiko  慶應義塾大学, 薬学部, 講師 (10327520)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords皮膚腫瘍学 / 癌幹細胞 / 腫瘍免疫 / 腫癌免疫
Research Abstract

We have previously isolated melanoma-stem cell like population in Side Population(SP). In this study, we analyzed genes expressed by hypoxia in those SP cells. We also found antibodies against novel cancer testis antigen specifically expressed by melanoma SP cells in melanoma patients. In addition, we have identified HLA-A 2402-restricted peptide in this cancer testis antigen. These results will be useful for development novel immunotherapy targeting cancer stem cells in melanoma patients.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (4 results)

All 2012

All Presentation (4 results)

  • [Presentation] New diagnostic and therapeutic target KU-MEL9 for chronic myeloid leukemia(CML)2012

    • Author(s)
      Maiko Matsushita, Takuma Suzuki, Naoya Tsutsumida, Shiro Iijima, Nobuo Tsukamoto, Yutaka Kawakami, Eri Matsuski, Shinichiro Okamoto, and Yutaka Hattori
    • Organizer
      米国癌研究学会2012年次総会
    • Place of Presentation
      シカゴ
    • Year and Date
      2012-04-02
    • Related Report
      2011 Final Research Report
  • [Presentation] New diagnostic and therapeutic target KU-MEL9 for chronic myeloid leukemia2012

    • Author(s)
      松下麻衣子
    • Organizer
      米国癌研究学会
    • Place of Presentation
      米国シカゴ(学会開催3月31日-4月4日)
    • Year and Date
      2012-04-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 慢性骨髄性白血病(CML)における新規治療標的としてのKU-MEL-9抗原の検討2012

    • Author(s)
      鈴木拓真、松下麻衣子、堤田直也、飯島史朗、塚本信夫、河上裕、松木絵里、岡本真一郎、服部豊
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌市
    • Year and Date
      2012-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 慢性骨髄性白血病における新規治療標的としてのKU-MEL9抗原の検討2012

    • Author(s)
      鈴木拓真、松下麻衣子
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌市
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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