Pathological analysis of de novo melanoma and therapy using novel melanoma model mice
| Project/Area Number |
22791092
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Chubu University |
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Principal Investigator |
KUMASAKA Mayuko 中部大学, 生命健康科学研究所, 研究員 (90469023)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | メラノーマ / モデルマウス / 色素細胞 |
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| Research Abstract |
We have performed a comparative study about de novo melanomaand nevus-associated melanoma which obtained from each model mice using pathologicaland biological method. As a result, a characteristic alteration of gene expression in de novomelanoma was found. By further analysis using human melanoma tissues, we suggest thepossibility that this gene is associated with melanoma tumorigenesis in relation to E,which is involved in de novo melanoma tumorigenesis.
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Report
(3 results)
Research Products
(28 results)
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[Journal Article] Enhanced carcinogenicity by coexposure to arsenic and iron and a novel remediation system for the elements in well drinking water.2012
Author(s)
Kumasaka MY, Yamanoshita O, Shimizu S, Ohnuma S, Furuta A, Yajima I, Nizam S,Khalequzzaman M, Shekhar HU, Nakajima T,Kato M.
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Journal Title
Arch Toxicol.
Volume: 87(3)
Pages: 439-447
Related Report
Peer Reviewed
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[Journal Article] A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation.2010
Author(s)
Kato M, Takeda K, Hossain K, Thang ND,Kaneko Y, Kumasaka M, Yamanoshita O,Uemura N, Takahashi M, Ohgami N, Kawamoto Y.
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Journal Title
J Cell Biochem.
Volume: 110(2)
Pages: 399-407
Related Report
Peer Reviewed
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