• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Pathological analysis of de novo melanoma and therapy using novel melanoma model mice

Research Project

Project/Area Number 22791092
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionChubu University

Principal Investigator

KUMASAKA Mayuko  中部大学, 生命健康科学研究所, 研究員 (90469023)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsメラノーマ / モデルマウス / 色素細胞
Research Abstract

We have performed a comparative study about de novo melanomaand nevus-associated melanoma which obtained from each model mice using pathologicaland biological method. As a result, a characteristic alteration of gene expression in de novomelanoma was found. By further analysis using human melanoma tissues, we suggest thepossibility that this gene is associated with melanoma tumorigenesis in relation to E,which is involved in de novo melanoma tumorigenesis.

Report

(3 results)
  • 2012 Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (28 results)

All 2013 2012 2011 2010 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (10 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Enhanced carcinogenicity by coexposure to arsenic and iron and a novel remediation system for the elements in well drinking water.2013

    • Author(s)
      Kumasaka YM, et al.
    • Journal Title

      Arch Toxicol.

      Volume: 87 Issue: 3 Pages: 439-447

    • DOI

      10.1007/s00204-012-0964-6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced carcinogenicity by coexposure to arsenic and iron and a novel remediation system for the elements in well drinking water.2012

    • Author(s)
      Kumasaka MY, Yamanoshita O, Shimizu S, Ohnuma S, Furuta A, Yajima I, Nizam S,Khalequzzaman M, Shekhar HU, Nakajima T,Kato M.
    • Journal Title

      Arch Toxicol.

      Volume: 87(3) Pages: 439-447

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced GNG2 expression levels in mouse malignant melanomas and human melanoma cell lines.2012

    • Author(s)
      Yajima I, Kumasaka MY, Naito Y,Yoshikawa T, Takahashi H, Funasaka Y, Suzuki T, Kato M.
    • Journal Title

      Am J Cancer Res.

      Volume: 2(3) Pages: 322-329

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Barium inhibits arsenic-mediated apoptotic cell death in human squamous cell carcinoma cells.2012

    • Author(s)
      Yajima I, Uemura N, Nizam S,Khalequzzaman M, Thang ND, Kumasaka MY,Akhand AA, Shekhar HU, Nakajima T, Kato M.
    • Journal Title

      Arch Toxicol.

      Volume: 86(6) Pages: 961-973

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novelhairless mouse model for malignant melanoma.2012

    • Author(s)
      Thang ND, Yajima I, Nakagawa K,Tsuzuki T, Kumasaka MY, Ohgami N, Ly TB,Iwamoto T, Watanabe D, Kato M.
    • Journal Title

      J Dermatol Sci.

      Volume: 65(3) Pages: 207-212

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced GNG2 expression levels in mouse malignant melanomas and human melanoma cell lines.2012

    • Author(s)
      矢嶋伊知朗
    • Journal Title

      American Journal of Cancer Research

      Volume: 2 Pages: 322-329

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Barium inhibits arsenic-mediated apoptotic cell death in human squamous cell carcinoma cells.2012

    • Author(s)
      Yajima I, et al.
    • Journal Title

      Arch Toxicol.

      Volume: 86 Issue: 6 Pages: 961-973

    • DOI

      10.1007/s00204-012-0848-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Barium Promotes Anchorage-Independent Growth and Invasion of Human HaCaT Keratinocytes via Activation of c-SRC Kinase2011

    • Author(s)
      Thang ND
    • Journal Title

      PLoS One

      Volume: 10 Issue: 3 Pages: 207-212

    • DOI

      10.1016/j.jdermsci.2011.10.010

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] L-cysteine as a regulator for arsenic-mediated cancer-promoting and anti-cancer effects2011

    • Author(s)
      Kato M, Kumasaka MY, Takeda K, Hossain K, Iida M, et al
    • Journal Title

      Toxicol In Vitro, Elsevier

      Volume: 25(3) Issue: 3 Pages: 623-629

    • DOI

      10.1016/j.tiv.2010.12.012

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation.2010

    • Author(s)
      Kato M, Takeda K, Hossain K, Thang ND,Kaneko Y, Kumasaka M, Yamanoshita O,Uemura N, Takahashi M, Ohgami N, Kawamoto Y.
    • Journal Title

      J Cell Biochem.

      Volume: 110(2) Pages: 399-407

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] c-RET molecule in malignant melanoma from oncogenic RET-carrying transgenic mice and human cell lines.2010

    • Author(s)
      Ohshima Y, Yajima I, Takeda K, Iida M,Kumasaka M, Matsumoto Y, Kato M.
    • Journal Title

      PLoS One.

      Volume: 5(4)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel mouse model for de novo Melanoma.2010

    • Author(s)
      Kumasaka MY, Yajima I, Hossain K, Iida M, Tsuzuki T, Ohno T, Takahashi M,Yanagisawa M, Kato M.
    • Journal Title

      Cancer Res.

      Volume: 70(1) Pages: 24-29

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel mouse model for de novo melanoma2010

    • Author(s)
      Kumasaka M
    • Journal Title

      Cancer Research

      Volume: 70 Pages: 24-29

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] c-RET molecule in malignant melanoma from oncogenic RET-carrying transgenic mice and human cell lines.2010

    • Author(s)
      Ohshima Y
    • Journal Title

      PLoS One.

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 発癌リスクを亢進させる重金属複合汚染に有効な浄化剤の開発2013

    • Author(s)
      矢嶋伊知朗、熊坂真由子、加藤昌志、
    • Organizer
      日本衛生学会第83回大会
    • Place of Presentation
      石川県(金沢大学)
    • Related Report
      2012 Final Research Report
  • [Presentation] 発癌リスクを亢進させる重金属複合汚染に有効な浄化剤の開発2013

    • Author(s)
      矢嶋伊知朗
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      石川県(金沢大学)
    • Related Report
      2011 Annual Research Report
  • [Presentation] メラノーマにおける GNG2 の機能2012

    • Author(s)
      矢嶋伊知朗、熊坂真由子、加藤昌志、
    • Organizer
      日本色素細胞学会第24回学術大会
    • Place of Presentation
      滋賀県(長浜バイオ大学)
    • Related Report
      2012 Final Research Report
  • [Presentation] メラノーマにおけるGNG2の機能2012

    • Author(s)
      矢嶋伊知朗
    • Organizer
      第24回日本色素細胞学会学術大会
    • Place of Presentation
      滋賀県(長浜バイオ大学)
    • Related Report
      2011 Annual Research Report
  • [Presentation] バリウムはc-SRC活性化を介してヒトケラチノサイト細胞株の癌化を誘導する2012

    • Author(s)
      矢嶋伊知朗
    • Organizer
      第82回日本衛生学会学術総会
    • Place of Presentation
      京都府(京都大学)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規メラノーマモデルマウスの樹立2010

    • Author(s)
      熊坂真由子、矢嶋 伊知朗 、飯田 真智子 、加藤昌志
    • Organizer
      日本色素細胞学会第23回学術大会、
    • Place of Presentation
      東京都(慈恵医大)
    • Year and Date
      2010-11-27
    • Related Report
      2012 Final Research Report
  • [Presentation] A novel mouse model for de novo melanoma2010

    • Author(s)
      熊坂真由子、矢嶋 伊知朗 、飯田 真智子 、加藤昌志
    • Organizer
      JSPS Asia-Africa Science Platform Program
    • Place of Presentation
      愛知県 (中部大学)
    • Year and Date
      2010-07-28
    • Related Report
      2012 Final Research Report
  • [Presentation] A novel mouse model for de novo melanoma2010

    • Author(s)
      熊坂真由子
    • Organizer
      JSPS Asia-Africa Science Platform Program
    • Place of Presentation
      中部大学(愛知県春日井市)
    • Year and Date
      2010-07-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規メラノーマモデルマウスの樹立と今後の展望2010

    • Author(s)
      熊坂真由子、矢嶋 伊知朗 、飯田 真智子 、加藤昌志
    • Organizer
      日本衛生学会第80回大会
    • Place of Presentation
      宮城県(宮城国際センター)
    • Year and Date
      2010-05-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規メラノーマモデルマウスの樹立と今後の展望2010

    • Author(s)
      熊坂真由子
    • Organizer
      日本衛生学会第80回大会
    • Place of Presentation
      宮城国際センター
    • Year and Date
      2010-05-10
    • Related Report
      2010 Annual Research Report
  • [Remarks] 中部大学生命健康科学研究所ホームページ

    • URL

      http://www.chubu.ac.jp/organization/institute/health_sciences/

    • Related Report
      2012 Final Research Report
  • [Remarks] 中部大学生命健康科学研究所ホームページ

    • URL

      http://stu.isc.chubu.ac.jp/LHS/laboratory/problem/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://web.mac.com/chubu5011/iWeb/1048E42C-1A07-482D-B891-27AC74B179FB/FF1D1736-3DD1-4695-BD0F-AC57F88E0CD1.html

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 浄化剤及び浄化方法2012

    • Inventor(s)
      加藤昌志、山ノ下理、熊坂真由子、古田昭男
    • Industrial Property Rights Holder
      中部大学
    • Industrial Property Number
      2012-007741
    • Filing Date
      2012-01-18
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi