| Project/Area Number |
22791094
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 皮膚免疫学 / 好塩基球 / PI3キナーゼ / PI3キナーゼ経路 / 慢性アレルギー性皮膚炎 / Th2サイトカイン / 脂質メディエータ / KOマウス |
|---|
| Research Abstract |
It has reported that basophils participate in chronic allergic dermatitis. In this study, we found that PI3-kinase pathway plays an important role in the activation of basophils. Interestingly, PI3-kinase inhibitor(s) significantly suppressed the production of Th2 cytokines and lipid mediators. In addition, treatment with PI3-kinase inhibitor partially blocked IgE-mediated allergic dermatitis in mice in vivo.
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