Contribution to cutaneous immunological diseases by new regulatory B cells

Research Project

Project/Area Number	22791099
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Dermatology
Research Institution	Research Institute, International Medical Center of Japan
Principal Investigator	NAKASHIMA Hiroko 独立行政法人国立国際医療研究センター, 皮膚科, 医師 (30549910)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	CD22 / 制御性B細胞 / 接触皮膚炎 / 接触過敏反応 / IL-10 / CD19 / B-1細胞
Research Abstract	CD22-/-mice showed delayed recovery from CHS reactions compared with wild type mice. Our current study reveals a defect in survival or retention in activated CD22-/-peritoneal B-1 cells and a regulatory role of peritoneal B-1a cells in CHS. Comparing with CHS in CD19-/-mice revealed that peritoneal B-1a cells are likely to suppress the late remission phase as "regulatory B cells". CD22 deficiency results in disturbed CHS remission by impaired retention or survival of peritoneal B-1a cells that migrate into lymphoid organs.