Contribution to cutaneous immunological diseases by new regulatory B cells
Project/Area Number |
22791099
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Dermatology
|
Research Institution | Research Institute, International Medical Center of Japan |
Principal Investigator |
NAKASHIMA Hiroko 独立行政法人国立国際医療研究センター, 皮膚科, 医師 (30549910)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | CD22 / 制御性B細胞 / 接触皮膚炎 / 接触過敏反応 / IL-10 / CD19 / B-1細胞 |
Research Abstract |
CD22-/-mice showed delayed recovery from CHS reactions compared with wild type mice. Our current study reveals a defect in survival or retention in activated CD22-/-peritoneal B-1 cells and a regulatory role of peritoneal B-1a cells in CHS. Comparing with CHS in CD19-/-mice revealed that peritoneal B-1a cells are likely to suppress the late remission phase as "regulatory B cells". CD22 deficiency results in disturbed CHS remission by impaired retention or survival of peritoneal B-1a cells that migrate into lymphoid organs.
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Report
(3 results)
Research Products
(3 results)