Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Research Abstract |
In this study, we clarified a unique convergence of2-AG-mediated retrograde signaling molecules at specific inhibitory synapses, termed invaginating synapses in the basolateral amygdala(BA). We also found that endocannabinoid is synthesized via activation of postsynaptic5-HT2A receptors, and regulates not only inhibitory presynaptic GABA release but also local serotonergic transmission around invaginating synapses in BA. These results suggest that the inhibition of presynaptic GABA or5-HT release via activation of the invaginating synapses in BA may play an important role for the fear extinction.
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