Molecular mechanisms of emotional behavior impairment induced by juvenile stress

• Project/Area Number: 22791101
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Hokkaido University
• Principal Investigator: YOSHIDA Takayuki 北海道大学, 大学院・医学研究科, 助教 (60374229)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 扁桃体 / カンナビノイド / セロトニン

Research Abstract

In this study, we clarified a unique convergence of2-AG-mediated retrograde signaling molecules at specific inhibitory synapses, termed invaginating synapses in the basolateral amygdala(BA). We also found that endocannabinoid is synthesized via activation of postsynaptic5-HT2A receptors, and regulates not only inhibitory presynaptic GABA release but also local serotonergic transmission around invaginating synapses in BA. These results suggest that the inhibition of presynaptic GABA or5-HT release via activation of the invaginating synapses in BA may play an important role for the fear extinction.

Research Products

• [Journal Article] Lithium, but not valproic acid or carbamazepine, suppresses impulsive-like action in rats (2012)
  • Author(s): Ohmura Y, Tsutsui-Kimura I, Kumamoto H, Minami M, Izumi T, Yamaguchi T, Yoshida T, Yoshioka M.
  • Journal Title: Psychopharmacology Volume: 219 Pages: 421-432
  • Peer Reviewed
• [Journal Article] Lithium, but not valproic acid or carbamazepine, suppresses impulsive-like action in rats (2012)
  • Author(s): Ohmura Y, Tsutsui-Kimura I, Kumamoto H, Minami M, Izumi T, Yamaguchi T, Yoshida T, Yoshioka M
  • Journal Title: Psychopharmacology (Berl) Volume: 219 Pages: 421-432
  • Peer Reviewed
• [Journal Article] Regulation of cerebral blood flow in the hippocampus by neuronal activation through the perforant path : Relationship between hippocampal blood flow and neuronal plasticity (2011)
  • Author(s): Hamadate N, Yamaguchi T, Sugawara A, Tsujimatsu A, Izumi T, Yoshida T, Ohmura Y, Yoshioka M.
  • Journal Title: Brain Res. Volume: 1415 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Juvenile stress attenuates the dorsal hippocampal postsynaptic5-HT(1A) receptor function in adult rats (2011)
  • Author(s): Matsuzaki H, Izumi T, Horinouchi T, Boku S, Inoue T, Yamaguchi T, Yoshida T, Matsumoto M, Togashi H, Miwa S, Koyama T, Yoshioka M.
  • Journal Title: Psychopharmacology Volume: 214 Pages: 1329-1337
  • Peer Reviewed
• [Journal Article] Retrieval of conditioned fear activates the basolateral and intercalated nucleus of amygdala (2011)
  • Author(s): Izumi T, Boku S, Shinmin W, Inoue T, Konno K, Yamaguchi T, Yoshida T, Matsumoto M, Watanabe M, Koyama T, Yoshioka M.
  • Journal Title: J Neurosci Res Volume: 89 Pages: 773-90
  • Peer Reviewed
• [Journal Article] Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus (2011)
  • Author(s): Yoshida T, Uchigashima M, Yamasaki M, Katona I, Yamazaki M, Sakimura K, Kano M, Yoshioka M, Watanabe M.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 108 Pages: 3059-3064
  • NAID: 10030575938
  • Peer Reviewed
• [Journal Article] Regulation of cerebral blood flow in the hippocampus by neuronal activation through the perforant path: Relationship between hippocampal blood flow and neuronal plasticity (2011)
  • Author(s): Hamadate N., Yamaguchi T., Sugawara A., Tsujimatsu A., Izumi T, Yoshida T, Ohmura Y, Yoshioka M.
  • Journal Title: Brain Res. Volume: 1415 Pages: 1-7
  • DOI: 10.1016/j.brainres.2011.08.008
  • Peer Reviewed
• [Journal Article] Juvenile stress attenuates the dorsal hippocampus postsynaptic 5-HI1Areceptor function in adult rats (2011)
  • Author(s): Hirokazu Matsuzaki
  • Journal Title: Psychopharmacology Volume: 214 Issue: 1 Pages: 329-337
  • DOI: 10.1007/s00213-010-1987-4
  • Peer Reviewed
• [Journal Article] Retrieval of Conditioned Fear Activates the Basolateral and Intercalated Nucleus of Amygdala (2011)
  • Author(s): Izumi, T.; Boku, S.; Shinmin, W., et al
  • Journal Title: Journal of Neuroscience Research Volume: 89(5) Issue: 5 Pages: 773-790
  • DOI: 10.1002/jnr.22592
  • Peer Reviewed
• [Journal Article] Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus (2011)
  • Author(s): Yoshida T, Uchigashima M, Yamasaki M, Katona I, Yamazaki M, Sakimura K, Kano M, Yoshioka M, Watanabe M
  • Journal Title: Proc Natl Acad Sci U S A Volume: 108 Pages: 3059-3064
  • NAID: 10030575938
  • Peer Reviewed
• [Journal Article] Liposome-encapsulated hemoglobin ameliorates impairment of fear memory and hippocampal dysfunction after cerebral ischemia in rats (2010)
  • Author(s): Hamadate N, Yamaguchi T, Sugawara A, Togashi H, Izumi T, Yoshida T, Ohmura Y, Yoshioka M.
  • Journal Title: J. Pharmacol Sci Volume: 114 Pages: 409-419
  • NAID: 10029891002
  • Peer Reviewed
• [Journal Article] Diazepam-induced increases of synaptic efficacy in the hippocampal-mPFC pathway are associated with its anxiolytic-like effect of rats (2010)
  • Author(s): Shikanai H, Izumi T, Matsumoto M, Togashi H, Yamaguchi H, Yoshida T, Yoshioka M.
  • Journal Title: J. Pharmacol Sci Volume: 114 Pages: 341-346
  • Peer Reviewed
• [Journal Article] Endogenous acetylcholine modulates impulsive action via alpha4beta2 nicotinic acetylcholine receptors in rats (2010)
  • Author(s): Tsutsui-Kimura I, Ohmura Y, Izumi T, Yamaguchi T, Yoshida T, Yoshioka M.
  • Journal Title: Eur J Pharmacol Volume: 641 Pages: 148-153
  • Peer Reviewed
• [Journal Article] Nicotine provokes impulsive-like action by stimulating alpha4beta2 nicotinic acetylcholine receptors in the infralimbic, but not in the prelimbic cortex (2010)
  • Author(s): Tsutsui-Kimura I, Ohmura Y, Izumi T, Yamaguchi T, Yoshida T, Yoshioka M.
  • Journal Title: Psychopharmacology Volume: 209 Pages: 351-359
  • Peer Reviewed
• [Journal Article] The serotonergic projection from the median raphe nucleus to the ventral hippocampus is involved in the retrieval of fear memory through the corticotropin-releasing factor type2receptor (2010)
  • Author(s): Ohmura Y, Izumi T, Yamaguchi T, Tsutsui-Kimura I, Yoshida T, Yoshioka M.
  • Journal Title: Neuropsychopharmacology Volume: 35 Pages: 1271-1278
  • NAID: 120002548777
  • Peer Reviewed
• [Journal Article] Liposome-encapsulated hemoglobin ameliorates impairment of fear memory and hippocampal dysfunction after cerebral ischemia in rats (2010)
  • Author(s): Hamadate N, Yamaguchi T, Sugawara A, Togashi H, Izumi T, Yoshida T, Ohmura Y, Yoshioka M
  • Journal Title: J.Pharmacol Sci. Volume: 114 Pages: 409-419
  • NAID: 10029891002
  • Peer Reviewed
• [Journal Article] Diazepam-induced increases of synaptic efficacy in the hippocampal-mPFC pathway are associated with its anxiolytic-like effect of rats (2010)
  • Author(s): Shikanai H, Izumi T, Matsumoto M, Togashi H, Yamaguchi H, Yoshida T, Yoshioka M
  • Journal Title: J.Pharmacol Sci. Volume: 114 Pages: 341-346
  • Peer Reviewed
• [Journal Article] Nicotine provokes impulsive-like action by stimulating alpha4beta2 nicotinic acetylcholine receptors in the infralimbic, but not in the prelimbic cortex (2010)
  • Author(s): Tsutsui-Kimura I, Ohmura Y, Izumi T, Yamaguchi T, Yoshida T, Yoshioka M
  • Journal Title: Psychopharmacology (Berl) Volume: 209 Pages: 351-359
  • Peer Reviewed
• [Journal Article] The serotonergic projection from the median raphe nucleus to the ventral hippocampus is involved in the retrieval of fear memory through the corticotropin-releasing factor type 2 receptor (2010)
  • Author(s): Ohmura Y, Izumi T, Yamaguchi T, Tsutsui-Kimura I, Yoshida T, Yoshioka M
  • Journal Title: Neuropsychopharmacology Volume: 35 Pages: 1271-1278
  • NAID: 120002548777
  • Peer Reviewed
• [Presentation] 扁桃体基底核におけるカンナビノイドとセロトニンによるシナプス伝達の相互調節機構 (2012)
  • Author(s): 吉田隆行
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2012-03-15
• [Presentation] 恐怖記憶消去に関連する扁桃体シナプスの機能的分子基盤 (2011)
  • Author(s): 吉田隆行
  • Organizer: 第41回日本神経精神薬理学会
  • Place of Presentation: 京王プラザ(東京)
  • Year and Date: 2011-10-28
• [Presentation] 恐怖記憶消去に関連する扁桃体シナプスの機能的分子基盤 (2011)
  • Author(s): 吉田隆行
  • Organizer: 第41回日本神経精神薬理学会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2011-10-28
• [Presentation] Relation of the cannabinoidergic and serotonergic system modulating inhibitory and excitatory synaptic transmission in the basal amygdala (2011)
  • Author(s): Takayuki Yoshida
  • Organizer: The 32nd Naito Conference on Biological basis of mental functions and disorders
  • Place of Presentation: Yatsugatake Royal Hotel(Yamanashi, Japan)
  • Year and Date: 2011-10-19
• [Presentation] Relation of the cannabinoidergic and serotonergic system modulating inhibitory and excitatory synaptic transmission in the basal amygdala (2011)
  • Author(s): Takayuki Yoshida
  • Organizer: The 32nd Naito Conference on Biological basis of mental functions and disorders
  • Place of Presentation: Yatsugatake Royal Hotel (Yamanashi, Japan)
  • Year and Date: 2011-10-19
• [Presentation] 扁桃体基底核の陥入型抑制性シナプスにおける内因性カンナビノイドシグナル伝達機構 (2011)
  • Author(s): 吉田隆行
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-09-17
• [Presentation] 扁桃体基底外側核におけるカンナビノイドおよびセロトニンを介するシナプス伝達調節機構 (2010)
  • Author(s): 吉田隆行
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター(兵庫)
  • Year and Date: 2010-09-03
• [Presentation] 扁桃体基底外側核における内因性カンナビノイドを介する逆行性シグナル伝達機構 (2010)
  • Author(s): 吉田隆行
  • Organizer: 第83回日本薬理学会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2010-03-16
• [Remarks]
  • URL: http://hokudaineuropharmacol.com/
• [Remarks]
  • URL: http://hokudaineuropharmacol.com/works/
• [Remarks]
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