Neuroanatomical and neurochemical substrates for visual hallucinations

• Project/Area Number: 22791104
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Tohoku University
• Principal Investigator: NISHIO Yoshiyuki 東北大学, 病院, 講師 (90451591)
• Research Collaborator: HIRAYAMA Kazumi 山形県立保健医療大学, 保健医療学部, 教授 (00218819) ; IIZUKA Osamu 東北大学, 病院, 助教 (50334660) ; MUGIKURA Syunji 東北大学, 大学院・医学系研究科, 講師 (20375017)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 幻視 / パレイドリア / アセチルコリン / レビー小体型認知症 / レピー小体型認知症 / パーキンソン病 / ドパミン / 視覚性注意

Research Abstract

Visual hallucinations are spontaneous phenomena and hard to detect in experimental settings. Tools to evoke visual hallucinations would enable functional neuroimaging investigations and therapeutic intervention studies. We previously devised a new experimental task to detect and measure hallucination-like illusions in patients with dementia with Lewy bodies (DLB) and Parkinson's disease. In the present study, we developed another task to evoke visual illusions, which is easier to administer and has simpler scoring system. Using this new test, we successfully evoked hallucination-like illusory responses in patients with DLB. The number of illusory responses was dramatically reduced by administration of donepezil, a cholinesterase inhibitor. The result suggests the relationship between visual hallucinations and cholinergic insufficiency in DLB.

Research Products

• [Journal Article] Delusions of death in a patient with right hemisphere infarction (2012)
  • Author(s): Nishio N and Mori E.
  • Journal Title: Cogn Behav Neurol Volume: 25(4) Issue: 4 Pages: 216-23
  • DOI: 10.1097/wnn.0b013e31827504c7
  • Peer Reviewed
• [Journal Article] Pareidolias : complex visual illusions in dementia with Lewy bodies. (2012)
  • Author(s): Uchiyama M, Nishio Y, Yokoi K, Imamura T, Shinomura T, Mori E.
  • Journal Title: Brain Volume: 135 Issue: 8 Pages: 2458-2469
  • DOI: 10.1093/brain/aws126
  • Peer Reviewed
• [Journal Article] Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease : a 3-year longitudinal study (2012)
  • Author(s): BabaT, Kikuchi A, Hirayama K, Nishio Y, Hosokai Y, Kanno S, Hasegawa T, Sugeno N, Konno M, Suzuki K, et al
  • Journal Title: Brain Volume: 135 Issue: 1 Pages: 162-169
  • DOI: 10.1093/brain/awr321
  • Peer Reviewed
• [Journal Article] Attentional Set-Shifting Deficit in Parkinson's Disease Is Associated with Prefrontal Dysfunction: An FDG-PET Study (2012)
  • Author(s): Yoichi Sawada, Yoshiyuki Nishio, Kyoko Suzuki, Kazumi Hirayama, Atsushi Takeda, Yoshiyuki Hosokai, Toshiyuki Ishioka, Yasuto Itoyama, Shoki Takahashi, Hiroshi Fukuda, Etsuro Mori
  • Journal Title: PLoS ONE Volume: 7(6) Issue: 6 Pages: e38498-e38498
  • DOI: 10.1371/journal.pone.0038498
  • Peer Reviewed
• [Journal Article] Pareidolias : complex visual illusions in dementia with Lewy bodies (2012)
  • Author(s): Uchiyama M, Nishio Y, Yokoi K, Hirayama K, Imamura T, Shimomura T, Mori E.Pareidolias : complex visual illusions in dementia with Lewy bodies
  • Journal Title: Brain Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] A validation study of the Japanese version of the Addenbrooke's Cognitive Examination-Revised. Dement Geriatr Cogn Dis Extra (2012)
  • Author(s): Kawata KHS, Hahimoto R, Nishio Y, Hayashi A, Ogawa N, Kanno S, Hiraoka K, Yokoi K, Iizuka O, Mori E
  • Journal Title: Dement Geriatr Cogn Dis Extra Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Counting-backward test for executive function in idiopathic normal pressure hydrocephalus (2012)
  • Author(s): Kanno S, Saito M, Hayashi A, Uchiyama M, Hiraoka K, Nishio Y, Hisanaga K, Mori E
  • Journal Title: Acta Neurol Scand Volume: (印刷中) Issue: 4 Pages: 279-286
  • DOI: 10.1111/j.1600-0404.2012.01644.x
  • Peer Reviewed
• [Journal Article] 血管性認知症の精神症状と行動異常:病変部位と病変量の効果について (2012)
  • Author(s): 西尾慶之, 森悦朗
  • Journal Title: Dementia Japan Volume: 26 Pages: 89-96
• [Journal Article] False item recognition in patients with Alzheimer's disease (2011)
  • Author(s): Nobuhito Abe
  • Journal Title: Neuropsychologia Volume: 49(7) Issue: 7 Pages: 1897-1902
  • DOI: 10.1016/j.neuropsychologia.2011.03.015
  • Peer Reviewed
• [Journal Article] Illusory misidentifications and cortical hypometabolism in Parkinson's disease (2011)
  • Author(s): Ishioka T, Hirayama K, Hosokai Y, Takeda A, Suzuki K, et al
  • Journal Title: Movement disorder Volume: 26 Issue: 5 Pages: 837-843
  • DOI: 10.1002/mds.23576
  • Peer Reviewed
• [Journal Article] Association of olfactory dysfunction and brain metabolism in Parkinson's disease (2011)
  • Author(s): Baba T, Takeda A, Kikuchi A, Hishio Y, Hosokai Y, Hirayama K, Hasegawa T, Sugeno N, Suzuki K, et al
  • Journal Title: Movement disorder Volume: 26 Issue: 4 Pages: 621-628
  • DOI: 10.1002/mds.23602
  • Peer Reviewed
• [Journal Article] Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease : a 3 year longitudinal study (2011)
  • Author(s): Baba T, Kikuchi A, Hirayama K, Nishio Y, Hosokai Y, Kanno S, Hasegawa T, Sugeno N, Konno M, Suzuki K, Takahashi S, Fukuda H, Aoki M, Itoyama Y, Mori E, Takeda A
  • Journal Title: Brain Volume: 135 Pages: 161-169
  • Peer Reviewed
• [Journal Article] Cognitive profile of idiopathic normal pressure hydrocephalus (2011)
  • Author(s): Saito M, Nishio Y, Kanno S, Uchiyama M, Hayashi A, Takagi M, Kikuchi H, Yamasaki H, Shimomura T, Iizuka O, Mori E
  • Journal Title: Dement Geriatr Cogn Dis Extra Volume: 1 Pages: 202-2011
  • Peer Reviewed
• [Journal Article] The effects of aging and Alzheimer's disease on associative recognition memory (2011)
  • Author(s): Hanaki R, Abe N, Fujii T, Ueno A, Nishio Y, Hiraoka K, Shimomura T, Iizuka O, Shinohara M, Hirayama K, Mori E
  • Journal Title: Neurol Sci Volume: 32 Pages: 1115-1122
  • Peer Reviewed
• [Journal Article] 間脳性健忘 (2011)
  • Author(s): 西尾慶之, 森悦朗
  • Journal Title: 高次脳機能研究 Volume: 31 Pages: 294-300
  • NAID: 10031128163
• [Journal Article] Neuroanatomy of neurobehavioral disturbance in left anterior thalamic infarction. (2011)
  • Author(s): Nishio Y, Hashimoto M, Ishii K, Mori E.
  • Journal Title: Journal of Neurology Neurosurg and Psychiatry Volume: (In press)
  • Peer Reviewed
• [Journal Article] False item recognition in patients with Alzheimer's disease. (2011)
  • Author(s): Abe N, Fujii T, Nishio Y, Iizuka O, Kanno S, Kikuchi H, Takagi M, Hiraoka K, Yamasaki H, Choi H, Hirayama K, Shinohara M, Mori E.
  • Journal Title: Neuropsychologia Volume: (In press)
  • Peer Reviewed
• [Journal Article] Illusory misidentifications and cortical hypometabolism in Parkinson's disease. (2011)
  • Author(s): Ishioka T, Hirayama K, Hosokai Y, Takeda A, Suzuki K, Nishio Y, Sawada Y, Takahashi S, Fukuda H, Itoyama Y, Mori E.
  • Journal Title: Movement Disorders Volume: (In press)
  • Peer Reviewed
• [Journal Article] Association of olfactory dysfunction and brain. Metabolism in Parkinson's disease. (2011)
  • Author(s): Baba T, Takeda A, Kikuchi A, Nishio Y, Hosokai Y, Hirayama K, Hasegawa T, Sugeno N, Suzuki K, Mori E, Takahashi S, Fukuda H, Itoyama Y.
  • Journal Title: Movement Disorders Volume: (In press)
  • Peer Reviewed
• [Journal Article] Is the midbrain involved in the manifestation of gait disturbance in idiopathic normal-pressure hydrocephalus? (2011)
  • Author(s): Hiraoka K, Yamasaki H, Takagi M, Saito M, Nishio Y, Iizuka O, Kanno S, Kikuchi H, Mori E.
  • Journal Title: Journal of Neurology Volume: (In press)
  • Peer Reviewed
• [Journal Article] 左右前頭葉の機能的差異 (2011)
  • Author(s): 西尾慶之, 森悦朗
  • Journal Title: Brain Medical Volume: (In press)
• [Journal Article] Changes in the volumes of the brain and cerebrospinal fluid spaces after shunt surgery in idiopathic normal-pressure hydrocephalus. (2010)
  • Author(s): Hiraoka K, Yamasaki H, Takagi M, Saito M, Nishio Y, Iizuka O, Kanno S, Kikuchi H, Kondo T, Mori E.
  • Journal Title: Journal of the Neurological Sciences Volume: 296 Pages: 7-12
  • Peer Reviewed
• [Journal Article] Corticolimbic gray matter loss in Parkinson's disease without dementia. (2010)
  • Author(s): Nishio Y, Hirayama K, Takeda A, Hosokai Y, Ishioka T, Suzuki K, Itoyama Y, Takahashi S, Mori E.
  • Journal Title: European Journal of Neurology Volume: 17 Pages: 1090-1097
  • Peer Reviewed
• [Journal Article] Logopenic progressive aphasia:第3の原発性進行性失語症 (2010)
  • Author(s): 小川七世, 西尾慶之
  • Journal Title: 神経心理 Volume: 26 Pages: 1403-1409
  • NAID: 10029842324
• [Journal Article] 認知症の画像診断-神経解剖学的基盤 (2010)
  • Author(s): 西尾慶之, 森悦朗
  • Journal Title: 画像診断 Volume: 30 Pages: 1403-1409
• [Presentation] Visual Illusions and hallucinations in Lewy body diseases (2013)
  • Author(s): Yoshiyuki Nishio
  • Organizer: The International Congress on Mental Dysfunction and other non-motor features In Parkinson's Disease
  • Place of Presentation: (Symposium presentation), Seoul, Korea
  • Year and Date: 2013-04-19
• [Presentation] Visual Illusions in dementia Lewy bodies (2013)
  • Author(s): Kayoko Yokoi, Yoshiyuki Nishio, Makoto Uchiyama, Etsuro Mori
  • Organizer: The International Conference On Alzheimer's disease and Parkinson's disease
  • Place of Presentation: (Poster presentation), Florence, Italy
  • Year and Date: 2013-03-07
• [Presentation] Lewy小体病の幻視:現実と非現実のはざまの知覚 (2012)
  • Author(s): 西尾慶之
  • Organizer: 新潟神経心理懇話会(招待口演)
  • Place of Presentation: 新潟
  • Year and Date: 2012-10-27
• [Presentation] レビー小体型認知症における複雑錯視 (2012)
  • Author(s): 西尾慶之,内山信,横井香代子,平山和美,今村徹,下村辰雄,森悦朗
  • Organizer: 2012年日本神経学会総会(一般口演)
  • Place of Presentation: 東京
  • Year and Date: 2012-05-25
• [Presentation] 間脳損傷と健忘 (2010)
  • Author(s): 西尾慶之, 森悦朗
  • Organizer: 第34回日本高次脳機能障害学会シンポジウム
  • Place of Presentation: 大宮
  • Year and Date: 2010-11-19
• [Presentation] Subcortical ischemic vascular dementia(SIVD)における行動異常 (2010)
  • Author(s): 西尾慶之, 森悦朗
  • Organizer: 第29回日本認知症学会ワークショップ
  • Place of Presentation: 名古屋
  • Year and Date: 2010-11-06
• [Presentation] Disruption of thalamocortical interconnections in neurobehavioral disturbance after left anterior thalamic infarction (2010)
  • Author(s): Yoshiyuki Nishio, Mamoru Hashimoto, Kazunari Ishii, Daisuke Ito, Shunji Mugikura, Shoki Takahashi, Etsuro Mori
  • Organizer: 135^<th> annual meeting of American Neurological Association
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2010-09-14
• [Presentation] パレイドリア：レビー小体型認知症における複雑錯視
  • Author(s): 西尾慶之，内山信，横井香代子，平山和美，今村徹，下村辰雄，森悦朗
  • Organizer: 第53回日本神経学会総会
  • Place of Presentation: 東京
• [Presentation] 新潟神経心理懇話会
  • Author(s): 西尾慶之
  • Organizer: レビー小体病の幻視：現実と非現実のはざまの知覚
  • Place of Presentation: 新潟
  • Invited