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Involvement of the psychological and biological factors in treatment resistance to major depression

Research Project

Project/Area Number 22791106
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionYamagata University

Principal Investigator

SUZUKI Akihito  山形大学, 医学部, 講師 (10396567)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Keywords精神病理学
Research Abstract

On March 2013, 35 subjects were enrolled in the present study. Twenty-two subjects completed the protocol, 9 were dropped out from the study, and 4 is in progress. I plan to summarize the results and make it public after 50 subjects complete the protocol.
As part of the present study, we found the following results; 1. the polymorphism of the brain-derived neurotrophic factor (BDNF) modulates the effects of parental rearing on harm avoidance and self-directedness, 2. the interaction between the BDNF polymorphism and parental rearing influences interpersonal sensitivity, 3. the BclI polymorphism of the glucocorticoid receptor gene is not involved in the characterization of personality traits, 4. the polymorphism of the p-glycoprotein gene affects formation of interpersonal sensitivity. These findings were made public in the form of an article and in the scientific meetings.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (9 results)

  • [Journal Article] Association study between glucocorticoid receptor gene polymorphisms and personality traits in healthy Japanese individuals2012

    • Author(s)
      Matsumoto Y, Suzuki A, Shibuya N, Sadahiro R, Kamata M, Goto K, Otani K
    • Journal Title

      Psychiatr Genet

      Volume: 22 Pages: 218-218

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction effect between the BDNF Val66Met polymorphism and parental rearing for interpersonal sensitivity in healthy subjects2012

    • Author(s)
      Suzuki A, Matsumoto Y, Shibuya N, Sadahiro R, Kamata M, Enokido M, Goto K, Otani K
    • Journal Title

      Psychiatry Res

      Volume: 200 Pages: 945-948

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction effect between the BDNF Val66Met polymorphism and parental rearing for interpersonal sensitivity in healthy subjects2012

    • Author(s)
      Suzuki A, Matsumoto Y, Shibuya N, Sadahiro R, Kamata M, Enokido M, Goto K, Otani K
    • Journal Title

      Psychiatry Research

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The brain-derived neurotrophic factor Val66 Met polymorphism modulates the effects of parental rearing on personality traits in healthy subjects2011

    • Author(s)
      Suzuki A, Matsumoto Y, Shibuya N, Sadahiro R, Kamata M, Goto K, Otani K
    • Journal Title

      Genes Brain Behav

      Volume: 10 Pages: 385-391

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The brain-derived neurotrophic factor Val66Met polymorphism modulates the effects of parental rearing on personality traits in healthy subjects.2011

    • Author(s)
      Suzuki A, Matsumoto Y, Shibuya N, Sadahiro R, Kamata M, Goto K, Otani K.
    • Journal Title

      Genes, Brain, and Behavior

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] うつ病親和性人格におけるP 糖蛋白の関与:MDR1 遺伝多型と対人関係敏感性との関連2012

    • Author(s)
      榎戸正則、鈴木昭仁、貞廣良一、松本祥彦、渋谷直史、鎌田光宏、大谷浩一
    • Organizer
      第22回日本臨床精神神経薬理学会
    • Place of Presentation
      宇都宮, 栃木県総合文化センター・宇都宮東武ホテルグランデ
    • Related Report
      2012 Final Research Report
  • [Presentation] 対人関係敏感性における脳由来神経栄養因子Val66Met 遺伝多型と両親の養育態度の相互作用の影響2012

    • Author(s)
      鈴木昭仁、松本祥彦、渋谷直史、貞廣良一、鎌田光宏、榎戸正則、大谷浩一
    • Organizer
      第34 日本生物学的精神医学会
    • Place of Presentation
      神戸, 神戸国際会議場
    • Related Report
      2012 Final Research Report
  • [Presentation] うつ病親和性人格におけるP糖蛋白の関与:MDR1遺伝多型と対人関係敏感性との関連2012

    • Author(s)
      榎戸正則、鈴木昭仁、貞廣良一、松本祥彦、渋谷直史、鎌田光宏、大谷浩一
    • Organizer
      日本臨床精神神経薬理学会
    • Place of Presentation
      宇都宮、栃木県総合文化センター・宇都宮東武ホテルグランデ
    • Related Report
      2012 Annual Research Report
  • [Presentation] 対人関係敏感性における脳由来神経栄養因子Val66Met遺伝多型と両親の養育態度の相互作用の影響2012

    • Author(s)
      鈴木昭仁、松本祥彦、渋谷直史、貞廣良一、鎌田光宏、榎戸正則、大谷浩一
    • Organizer
      日本生物学的精神医学会
    • Place of Presentation
      神戸、神戸国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Interaction effects between the brain-derived neurotrophic factor Val66Met polymorphism and parental rearing on personality traits in healthy subjects2011

    • Author(s)
      Suzuki A, Matsumoto Y, Shibuya N, Sadahiro R,KamataM,Otani K
    • Organizer
      19th European Congress of Psychiatry
    • Place of Presentation
      Austria Center Vienna, Vienna, Austria
    • Related Report
      2012 Final Research Report
  • [Presentation] Association study between glucocorticoid receptor polymorphisms and personality traits in healthy subjectsAssociation study between glucocorticoid receptor polymorphisms and personality traits in healthy subjects2011

    • Author(s)
      Matsumoto Y, Suzuki A, Shibuya N, Sadahiro R, Kamata M, Otani K
    • Organizer
      19th European Congress of Psychiatry
    • Place of Presentation
      Austria Center Vienna, Vienna, Austria
    • Related Report
      2012 Final Research Report
  • [Presentation] Interaction effects between the brain-derived neurotrophic factor Val66Met polymorphism and parental rearing on personality traits in healthy subjects2011

    • Author(s)
      Suzuki A, Matsumoto Y, Shibuya N, Sadahiro R, Kamata M, Otani K
    • Organizer
      19th European Congress of Psychiatry
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳由来神経栄養因子Val66Met 遺伝多型と両親の養育態度の相互作用が人格特徴に与える影響2010

    • Author(s)
      鈴木昭仁, 松本祥彦, 渋谷直史, 貞廣良一, 鎌田光宏, 大谷浩一
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      北九州, リーガロイヤルホテル小倉
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳由来神経栄養因子Val66Met遺伝多型と両親の養育態度の相互作用が人格特徴に与える影響2010

    • Author(s)
      鈴木昭仁、松本祥彦、渋谷直史、貞廣良一、鎌田光宏、大谷浩一
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      北九州
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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